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Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody

Antigen

Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)
Synonyms Flk1, Ly73, Flk-1, Krd-1, VEGFR2, VEGFR-2, sVEGFR-2, 6130401C07, FLK1, CD309, VEGFR, Vegfr-2, MGC93590, KDR, FLK-1, flk-1, vegfr-2
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
2 references available
Catalog no. ABIN99318
Quantity
Price 598.40 $   Plus shipping costs $45.00
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anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody

Additional Information
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Alternative name Flk-1 (Flk-1/KDR/VEGFR2)
Immunogen A synthetic peptide derived from the C-terminus of the precursor form of the mouse Flk-1.
Format Ig-fraction, Purified
Specificity This antibody reacts with a 180 kD protein, known as Flk-1/KDR/Vascular endothelial growth factor receptor 2. Flk-1 is a cell membrane receptor kinase. Flk-1 is a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis. This antibody cross reacts with mouse and rat.

Application Details
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Application Notes Titer/Working Dilution: This antibody may be diluted to a titer of 1:50-1:100 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions should be determined by the user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Positive Control: Angiosarcoma. Cellular localization: Cytoplasmic Other Applications: Western Blotting
Concentration 100ug/ml approximately
Purification Ig-fraction,Purified
Buffer Purified immunoglobulin fraction of rabbit antiserum against human Flk-1 containing sodium azide as preservative.
Storage Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.
Research Area Cytokines, Receptors
Restrictions For Research Use. CE-certified for In Vitro Diagnostics (IVD) Use in the European Union

Publications
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Quinn, Peters, De Vries et al.: "Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 16, pp. 7533-7, 1993 (PubMed).

Ankoma-Sey, Matli, Chang et al.: "Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing." in: Oncogene, Vol. 17, Issue 1, pp. 115-21, 1998 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)", type "Antibodies"
Hosts Rabbit (198), Mouse (33), Rat (16), Escherichia Coli (E. coli) (2), Goat (2), Chicken (1)
Reactivities Human (203), Mouse (Murine) (109), Rat (Rattus) (78), Dog (Canine) (20), Chicken (19), Cow (Bovine) (19), Pig (Porcine) (18), Cat (Feline) (1)
Applications Western Blotting (WB) (166), Immunohistochemistry (IHC) (89), ELISA (85), Immunofluorescence (IF) (71), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (60), Flow Cytometry (FACS) (57), Immunoprecipitation (IP) (17), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (5), Neutralization (Neut) (5), Functional Studies (Func) (3), Immunocytochemistry (ICC) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Dot Blot (Dot) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Biotin (14), PE (4), APC (2), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), FITC (2), PE,Cy5.5 (2), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), E-Tag (1), Gold (1), HRP (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pTyr951 (20), C-Term (18), pTyr1175 (15), pTyr1214 (13), Internal Region (5), pTyr996 (4), N-Term (3), Tyr1175 (3), Tyr1214 (3), Tyr951 (3), pTyr1054 (3), pTyr1059 (3), AA 1158-1345 (2), pY1054 (2), AA 1057-1061 (1), AA 20-762 (1), AA 20-764 (1), Extracellular Domain (1), Extracellular,AA 20-764 (1), pTyr1054, pTyr1059 (1), pY951 (1)