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Antigène
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11beta-Hydroxysteroid Dehydrogenase (Type 1)
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Immunogène
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Human 11beta-HSD1 amino acids
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Reactivité
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Human, Mouse (Murine), Rat
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Type anticorps
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Polyclonal
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Description
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11beta-Hydroxysteroid dehydrogenase (Type 1) (11beta-HSD1) catalyzes the conversion of inactive cortisone to active cortisol in adipose tissue. mRNA and protein for this enzyme have been detected in a wide range of tissues including liver, kidney, testis, lung, heart, and colon. The enzyme's expression is developmentally regulated, suggesting its importance in regulation of glucocorticoid action during embryonic development. Over-expression of 11beta-HSD1 results in visceral obesity and metabolic syndrome including insulin-resistant diabetes, hyperlipidemia, and hyperphagia. Cayman Chemical's 11beta-HSD1 Polyclonal Antibody can be used for WB and IHC (formalin-fixed paraffin-embedded sections) analysis for 11beta-HSD1 on samples of human, murine, and rat origin. Other applications for use of this antibody have not yet been tested. The antibody detects a 32 kDa protein in human, murine, and rat liver samples by WB analysis.
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Hôte
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Rabbit
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Specificité
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Human 11beta-HSD1: +, Murine 11beta-HSD1: +, Rat 11beta-HSD1: +
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PANIER
AIDE
Antigènes
