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Product details for 14-3-3 gamma (Human) antibody
14-3-3 gamma (Human) antibody
Overview
| Antigen: | 14-3-3 gamma |
| Antibody Type: | Monoclonal |
| Application: | Immunoprecipitation (IP), Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 279,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN144293 |
| Availability: | 7 to 10 days until shipment |
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Additional Information: 14-3-3 gamma (Human) antibody
| Antigen | 14-3-3 gamma |
| Immunogen | Recombinant full length protein (Human 14-3-3 gamma). |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Format | Liquid |
| Isotype | IgG »Matching secondary antibodies |
| Description | Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. 14-3-3 proteins regulate many cellular processes that are important in cancer biology, such as apoptosis and cell cycle checkpoints. Evidence indicates 14-3-3 is required for Raf1 kinase activity and phosphorylation amoung many other functions. Levels of 14-3-3 gamma in the brain are significantly increased in Alzheimers disease and Down syndrome. |
| Clone | 3F8 |
| Host | Mouse |
| Specificity | Shows no crossreactivity with other isoforms of 14-3-3. |
Application Details: 14-3-3 gamma (Human) antibody
| Application | Immunoprecipitation (IP), Western Blotting (WB) |
| Application Notes | IP: Use at an assay dependent dilution. WB: Use at a concentration of 1-2 ug/ml. Predicted molecular weight: 30 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Format | Liquid |
| Concentration | 0.2 mg/ml |
| Purity | Protein G purified |
| Buffer | Preservative: 0.09% Sodium AzideConstituents: 0.2% BSA, 10mM PBS. pH 7.4 |
| Research Area | Transcription Factors |
| Restrictions | For research use only |
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