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Product details for 14-3-3 tau (Human) antibody
14-3-3 tau (Human) antibody
Overview
| Antigen: | 14-3-3 tau |
| Antibody Type: | Monoclonal |
| Application: | Immunoprecipitation (IP), Western Blotting (WB) |
| Reactivity: | Human, Mouse (Murine), Rat, Bovine |
| Host: | Mouse |
| Quantity: | |
| Price: | 247,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN143763 |
| Availability: | 7 to 10 days until shipment |
Additional Information: 14-3-3 tau (Human) antibody
| Antigen | 14-3-3 tau |
| Immunogen | Recombinant full length protein. |
| Reactivity | Human, Mouse (Murine), Rat, Bovine |
| Antibody Type | Monoclonal |
| Format | Liquid |
| Isotype | IgG1 »Matching secondary antibodies |
| Description | At least seven isoforms comprise the highly conserved 14-3-3 family of homo and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. These multifunctional proteins bind and modulate the function of a wide array of cellular proteins. They exist mainly as dimers with a monomeric molecular mass of approximately 30 kDa and have an acidic isoelectric point of 4.5-5. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and through interaction with bad, prevents apoptosis. 14-3-3 plays a dual role in Raf-1 activation. It helps to keep Raf-1 in an inactive state by binding to phophoserine-259 and the cysteine-rich domain (DRD). Interactions of 14-3-3 at the phosphoserine-621 may be required for Raf |
| Clone | 3B9 |
| Host | Mouse |
| Specificity | ABIN143763 recognises theta/tau isoform.The antibody does not react with the 14-3-3 zeta isoform. |
Application Details: 14-3-3 tau (Human) antibody
| Application | Immunoprecipitation (IP), Western Blotting (WB) |
| Application Notes | IP: Use at an assay dependent dilution. WB: Use at a dilution of 1/5000. Detects a band of approximately 31 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | 1 mg/ml |
| Purity | Protein G purified |
| Buffer | 20 mM sodium phosphate, 150 mM sodium chloride, 50% Glycerol, PBS. pH 7.5 |
| Research Area | Transcription Factors |
| Restrictions | For research use only |
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