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Product details for 15-Lipoxygenase-2 antibody
15-Lipoxygenase-2 antibody
Overview
| Antigen: | 15-Lipoxygenase-2 |
| Antibody Type: | Polyclonal |
| Application: | Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Rabbit |
| Quantity: | |
| Price: | 320,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN110239 |
| Availability: | 1 to 7 days before shipment |
Additional Information: 15-Lipoxygenase-2 antibody
| Antigen | 15-Lipoxygenase-2 |
| Immunogen | Human 15-lipoxygenase-2 (15-LO-2) amino acids |
| Reactivity | Human |
| Antibody Type | Polyclonal |
| Description | Two types of 15-LO have been discovered and characterized, both of which metabolize arachidonic acid (AA) to produce 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE). 15-LO-1 oxygenates AA at both C15 and C12, whereas 15-LO-2 exclusively oxygenates C15 of AA. Human 15-LO-2 has a molecular mass of approximately 76 kDa and exhibits approximately 40% identity to the reticulocyte 15-LO-1. Expression of 15-LO-2 appears to be restricted to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues. The protein levels and enzymatic activity of 15-LO-2 are both down-regulated in prostate cancer compared with normal and benign prostate tissues, implicating a possible protective role for 15-LO-2 against tumor formation. Cayman Chemical's 15-LO-2 polyclonal antibody can be used for western blot analysis for 15-LO-2 on samples of human origin. Other applications for use of this antibody have not yet been tested. |
| Host | Rabbit |
| Specificity | Human 15-Lipoxygenase-2: +, 15-Lipoxygenase-1 (rabbit reticulocyte): -, 12-Lipoxygenase-1 (porcine leukocytes): - |
Application Details: 15-Lipoxygenase-2 antibody
| Application | Western Blotting (WB) |
| Buffer | Affinity-purified IgG |
| Storage | 1 year |
| Research Area | Enzymes |
| Restrictions | For Research only |
Publications: 15-Lipoxygenase-2 antibody
| Publications | Shappell, S.B., Gupta, R.A., Manning, S., et al. 15S-hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells. Cancer Res 61, 497-503 (2001). |
External Information: 15-Lipoxygenase-2 antibody
| Google Scholar | Find more references for antigen 15-Lipoxygenase-2 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen 15-Lipoxygenase-2 (Bioinformatic Harvester (EMBL)) |
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