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Product details for APP (N) (Human) antibody
APP (N) (Human) antibody
Overview
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| Antigen: | APP (N) |
| Antibody Type: | Monoclonal |
| Application: | Western Blotting (WB), Immunoprecipitation (IP) |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 315,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN180082 |
| Availability: | 10 days until shipment |
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Additional Information: APP (N) (Human) antibody
| Antigen | APP (N) |
| Immunogen | N-terminal portion of Recombinant Human APP |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Isotype | IgG1 »Matching secondary antibodies |
| Description | Amyloid precursor protein (APP) is precursor protein of Amyloid which is major constituent of senile plaque in Alzheimer's disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative splicing of common precursor mRNA. Processing of APP occurs by two major pathways, non-amyloidogenic pathway and amyloidogenic pathway. The non-amyloidogenic pathway is mediated by and -secretases and gives rise to a large fragment known as soluble APP (sAPP ) and a small 3 kDa peptide known as p3. On the other hand, the Amyloidogenic pathway is mediated by - and -secretases and yields soluble APP (sAPP) and Amyloid . The physiologic function of APP itself is not clear, however, it is supposed that the function of APP in neuron system is different from that in other organ. |
| Clone | 10D1 |
| Host | Mouse |
| Specificity | Does not crossreact with Mouse. This antibody can detect all isoforms of APP695, APP751 and APP770, and soluble APP (sAPP and ). |
Application Details: APP (N) (Human) antibody
| Application | Western Blotting (WB), Immunoprecipitation (IP) |
| Application Notes | This antibody can be used for western blotting in concentration of about 2 ug/ml.:This antibody can be used for immunoprecipitation in concentration of about 3 ug/ml. |
| Purification | Protein A |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 Reconstitution: 1.0 ml distilled water will be added to the product, then its concentration comes to 100 ug/ml |
| Storage | Lyophilized product, 5 years at 2 8 : Solution, 2 years at 20 |
| Restrictions | For Research Use only |
External Information: APP (N) (Human) antibody
| Google Scholar | Find more references for clone 10D1 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen APP (N) (Bioinformatic Harvester (EMBL)) |
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