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Product details for APP phosphorylated (Human, Mouse) antibody
APP phosphorylated (Human, Mouse) antibody
Overview
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| Antigen: | APP phosphorylated |
| Antibody Type: | Polyclonal |
| Application: | Western Blotting (WB), Immunoprecipitation (IP) |
| Reactivity: | Human, Mouse (Murine) |
| Host: | Rabbit |
| Quantity: | |
| Price: | 315,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN180252 |
| Availability: | 10 days until shipment |
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Additional Information: APP phosphorylated (Human, Mouse) antibody
| Antigen | APP phosphorylated |
| Immunogen | Synthetic peptide of Phosphorylated part of APP (DAAVpTPEE) Purification: Purified with antigen peptide |
| Reactivity | Human, Mouse (Murine) |
| Antibody Type | Polyclonal |
| Isotype | IgG »Matching secondary antibodies |
| Description | Amyloid precursor protein (APP) is precursor protein of Amyloid which is major constituent of senile plaque in Alzheimer's disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative splicing of common precursor mRNA (ref.1). Processing of APP occurs by two major pathways, non-amyloidogenic pathway and amyloidogenic pathway.The non-amyloidogenic pathway is mediated by - and -secretases and gives rise to a large fragment known as soluble APP(sAPP) and a small 3 kDa peptide known as p3. On the other hand, the Amyloidogenic pathway is mediated by- and- secretases and yields soluble APP (sAPP) and Amyloid . APP is expressed at many of tissue within an organism. It is supposed that the function of APP in neuron system is different from that in other organ.In nerve cells, APP containing an N- or O-type sugar chain modification (mature APP) is phosphorylated at the Thr668 position (APP695) by the actions of Cdk5 and c-Jun NH2-terminal kinase (JNK), which are nerve-specifically activated, and becomes translocated to the cell membrane and neuritis (ref. 2-4). It has been considered that the phosphorylation induces structural changes in the cytoplasmic domain of APP and influences A production (ref.5-6). Regulation of the bonding of APP with FE65 is believed to be involved in information transmission (ref. 6). |
| Host | Rabbit |
| Specificity | Reacts with human and mouse, and not reacts with nonphosphorylated APP. |
Application Details: APP phosphorylated (Human, Mouse) antibody
| Application | Western Blotting (WB), Immunoprecipitation (IP) |
| Application Notes | This antibody can be used for western blotting in concentration of 2-5 ug /mL.: This antibody can be used for immuno-precipitation in concentration of about 3 ug /mL. |
| Purification | Antigen peptide |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 Reconstitution: 1.0 mL deionized water will be added to the product (The conc. comes up 100 ug /mL) |
| Storage | Lyophilized product, 5 years at 2 8 |
| Restrictions | For Research Use only |
External Information: APP phosphorylated (Human, Mouse) antibody
| Google Scholar | Find more references for antigen APP phosphorylated on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen APP phosphorylated (Bioinformatic Harvester (EMBL)) |
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