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Product details for Bcl-1/cyclin D1 (Human) antibody
Bcl-1/cyclin D1 (Human) antibody
Overview
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| Antigen: | Bcl-1/cyclin D1 |
| Antibody Type: | Monoclonal |
| Application: | Immunohistochemistry (IHC), Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 315,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN180070 |
| Availability: | 10 days until shipment |
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Additional Information: Bcl-1/cyclin D1 (Human) antibody
| Antigen | Bcl-1/cyclin D1 |
| Immunogen | Recombinant Human PRAD1/cyclin D1 (E. coli) |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Isotype | IgG2a »Matching secondary antibodies |
| Description | Bcl-1/Cyclin D1 belongs to the G1 cyclins and plays a key role in cell cycle regulation during the G1/S transition by cooperating with cyclin-dependent kinases (CDKs). Its overexpression may lead to growth advantage for tumor cells by way of cell cycle progression, and actually it has been reported in various human cancers, e.g., esophageal, breast, and bladder carcinomas. Among hematolymphoid malignancies, cyclin D1 overexpression resulting from translocational activation has also been recognized in a subset of B-chronic lymphocytic leukemia (B-CLL), multiple myeloma, splenic marginal zone lymphoma, hairy cell leukemia, and mantle cell lymphoma. |
| Clone | 5D4 |
| Host | Mouse |
| Specificity | Cross-react with cyclin D2 |
Application Details: Bcl-1/cyclin D1 (Human) antibody
| Application | Immunohistochemistry (IHC), Western Blotting (WB) |
| Application Notes | This antibody can be stained in formalin fixed paraffin embedded tissues after microwave treatment by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 2-5 ug/ml, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 2-5 ug/ml. |
| Purification | Protein A |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1 ml distilled water will be added to the product |
| Storage | Lyophilized product, 5 years at 2 8 : Solution, 2 years at 20 |
| Research Area | Cancer |
| Restrictions | For Research Use only |
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