C Reactive Protein (Human) antibody

Overview

Antigen	C Reactive Protein
Immunogen	Full length native protein(Human).
Reactivity	Human
Antibody Type	Polyclonal
Format	Liquid
Isotype	IgY »Matching secondary antibodies
Description	C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Meas
Host	Chicken

Application	ELISA, Western Blotting (WB)
Application Notes	ELISA: Use at a concentration of 0.1 ug/ml. WB: Use at an assay dependent dilution. Predicted molecular weight: 117.5 kDa. Tissue or cell immunostaining: Use at a dilution of 1/200. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Concentration	1 mg/ml
Purity	Immunogen affinity purified
Buffer	Preservative: NoneConstituents: PBS
Research Area	Serum/Plasma Proteins, Inflammation
Restrictions	For research use only

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