Product details for  CD135 Human antibody
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CD135 Human antibody

Overview

Antigen: CD135
Antibody Type: Monoclonal
Application: Flow Cytometry (FACS)
Conjugate: PE/Cy5
Reactivity: Human
Host: Mouse
Quantity: 100 tests (Product variants)
Price: 307,00 €   (Plus shipping costs and VAT)
Order number: ABIN179886
Availability: Ships within 7 to 10 days
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Additional Information:  CD135 Human antibody

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Antigen CD135
Immunogen BV-173 pro-B cell line
Reactivity Human
Antibody Type Monoclonal
Isotype Mouse IgG1 Mouse IgG1, kappa »Matching secondary antibodies
Description CD135 is a 130-160 type III tyrosine kinase receptor expressed on CD34+ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML-BC. CD135, also known as FMS-like tyrosine kinase-3, FLT3, STK-1, and Flk-2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation and has been shown to interact with Grb2, SOCS1, VAV1, and Shc. Distribution: Expressed on CD34 hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. Also expressed on AML, ALL and CML-BC tumor cells Function: Tyrosine kinase growth factor receptor involved in the growth and differentiation of primitive hematopoietic cells Synonyms: FMS-like tyrosine kinase-3, FLT-3, STK-1, Flk-2 Structure: Member of the immunoglobulin supergene family, type 3 tyrosine kinase receptor, 130-160 kD
Clone BV10A4H2
Host Mouse

Application Details:  CD135 Human antibody

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Application Flow Cytometry (FACS)
Application Notes Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 µl per 1 million cells or 20 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Conjugate PE/Cy5
Purification The antibody was purified by affinity chromatography, and conjugated with PE/Cy5 under optimal conditions. The solution is free of unconjugated PE/Cy5 and unconjugated antibody.
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Storage The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Research Area CD Antigens
Restrictions For Research Use only

External Information:  CD135 Human antibody

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EMBL Harvester Search human, mouse or rat genome for antigen CD135 (Bioinformatic Harvester (EMBL))