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Product details for CD163 Human antibody
CD163 Human antibody
Overview
| Antigen: | CD163 |
| Antibody Type: | Monoclonal |
| Application: | Flow Cytometry (FACS) |
| Conjugate: | Biotin |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 93,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN179987 |
| Availability: | Ships within 7 to 10 days |
Additional Information: CD163 Human antibody
| Antigen | CD163 |
| Immunogen | Human monocytes |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Isotype | Mouse IgG1 Mouse IgG1, kappa »Matching secondary antibodies |
| Description | CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, Hemoglobin-Haptoglobin Complex Receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kuffer cells, monocytes, subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP) resulting in soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammation diseases. Distribution: Monocytes, macrophages, Kuffer cells, subset of dendritic cells, subset of hematopoietic stem/progenitor cells Function: Clearance of haptoglobin-hemoglobin complex, regulation of cytokine production by macrophages Synonyms: GHI/61, M130, RM3/1, p155, Hemoglobin/Haptoglobin Complex Receptor, macrophage-associated antigen, ED2(rat), Macrophage marker Structure: 134 kD (non-reduced)/155 kD (reduced) glycoprotein, Scavenger receptor superfamily |
| Clone | RM3-1 |
| Host | Mouse |
Application Details: CD163 Human antibody
| Application | Flow Cytometry (FACS) |
| Application Notes | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is < 0.5 µg per 10 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Conjugate | Biotin |
| Purification | The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin. |
| Buffer | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Storage | The antibody solution should be stored undiluted at 4°C. Do not freeze. |
| Research Area | CD Antigens |
| Restrictions | For Research Use only |
Product variants
External Information: CD163 Human antibody
| Google Scholar | Find more references for clone RM3-1 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen CD163 (Bioinformatic Harvester (EMBL)) |
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