CD40 Human antibody

Overview

Antigen	CD40
Reactivity	Human
Antibody Type	Monoclonal
Isotype	Mouse IgG1 Mouse IgG1, kappa »Matching secondary antibodies
Description	CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The G28.5 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA. Distribution: B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts Function: B cell differentiation, costimulation, isotype class-switching, rescues B cells from apoptosis Synonyms: BP50, TNFRSF5 Structure: TNFR superfamily, type I glycoprotein, 48 kD
Clone	G28-5
Host	Mouse

Application	Flow Cytometry (FACS)
Application Notes	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Additional reported applications (for the relevant formats) include: B cell bioassays. For immunofluorescent staining, the suggested use of this reagent is 20 µl per 1 million cells or 20 µl per 100 µl of whole blood.
Conjugate	FITC
Purification	The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Buffer	Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Storage	The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Research Area	CD Antigens
Restrictions	For Research Use only

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