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Product details for CXCR1 (Human) antibody
CXCR1 (Human) antibody
Overview
| Antigen: | CXCR1 |
| Antibody Type: | Monoclonal |
| Application: | Flow Cytometry (FACS), Inhibition Assay (Inhib) |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 368,42 $ (Plus shipping costs and VAT, Invoice in EUR) |
| Order number: | ABIN144773 |
| Availability: | 7 to 10 days until shipment |
Additional Information: CXCR1 (Human) antibody
| Antigen | CXCR1 |
| Immunogen | Human CXCR1 transfected NSO mouse myeloma cells. |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Format | Liquid |
| Isotype | IgG2b »Matching secondary antibodies |
| Description | Chemokines have been sub-divided into families on the basis of the relative position of their cysteine residues. The alpha and beta families, with four cysteine residues, are the largest and best characterized. In the alpha family, one amino acid separates the first two cysteine residues (CXC), in the beta family the two cysteine residues (CC) are adjacent to each other. The alpha chemokines that contain the N-terminal Glu-Leu-Arg amino acid sequence (ELR-motif) are chemotactic for neutrophils (such as IL8), while those that do not, act on lymphocytes (such as IP10 and MIG). Examples of chemokines under the beta family category are MCP1-5 and RANTES. The chemokine lymphotactin belongs to the gamma family, with only two cysteines (C), and the recently described fractalkine or neurotactin is a member of the delta family and has the first two cysteine residues separated by three amino-acids (CXXXC). Chemokines bind to specific G protein-coupled cell surface receptors on target cells. |
| Clone | 42705-11 |
| Host | Mouse |
| Specificity | Human CXCR1 reacts with CXCR1 transfected cells and not with the parent cell line by flow cytometry. The antibody shows no cross-reactivity with human CXCR2. |
Application Details: CXCR1 (Human) antibody
| Application | Flow Cytometry (FACS), Inhibition Assay (Inhib) |
| Application Notes | FACS: Use 10ul for 10^5-6human blood cells. Inhib: For neutralization, a working concentration of 0.1-0.3 u g/ ml of CXCR1 (in the presence of 10 u g/ ml CXCR2, will block 50% of the bioactivity due to 1 ug/ml recombinant human IL8 in an assay measuring myeloperoxidase released from human granulocytes. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | 0.5 mg/ml |
| Purity | Protein G purified |
| Buffer | Preservative: NoneConstituents: PBSEndotoxin level is < 10 ng per mg antibody as determined by the LAL method. |
| Restrictions | For research use only |
External Information: CXCR1 (Human) antibody
| Google Scholar | Find more references for clone 42705-11 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen CXCR1 (Bioinformatic Harvester (EMBL)) |
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