BASKET
HELP
Product details for Cyclin D1 (Human) antibody
Cyclin D1 (Human) antibody
Overview
| Antigen: | Cyclin D1 |
| Antibody Type: | Polyclonal |
| Application: | Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB) |
| Reactivity: | Human, Rat, Mouse (Murine) |
| Host: | Rabbit |
| Quantity: | |
| Price: | 516,61 $ (Plus shipping costs and VAT, Invoice in EUR) |
| Order number: | ABIN151502 |
| Availability: | Ships in 7 to 10 days |
Additional Information: Cyclin D1 (Human) antibody
| Antigen | Cyclin D1 |
| Immunogen | Full length fusion protein corresponding to the human gene sequence. |
| Reactivity | Human, Rat, Mouse (Murine) |
| Antibody Type | Polyclonal |
| Format | Serum |
| Description | Cyclin D1 (also known as G1/S-specific cyclin D1, PRAD1 oncogene, BCL-1 oncogene,and PRAD1: parathyroid adenomatosis 1) is encoded by a gene that belongs to thehighly conserved cyclin family. Cyclins are characterized by a dramatic periodicity inprotein abundance throughout the cell cycle and function as regulators of CDK kinases.Different cyclins exhibit distinct expression and degradation patterns, which contribute tothe temporal coordination of each mitotic event. Cyclin D1 forms a complex with andfunctions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cellcycle G1/S transition. This protein has been shown to interact with tumor suppressorprotein Rb and the expression of this gene is regulated positively by Rb. Mutations,amplification and overexpression of this gene, which alters cell cycle progression, areobserved frequently in a variety of tumors and may contribute to umorigenesis. |
| Host | Rabbit |
| Specificity | Antiserum will specifically react with a 35 kDa Cyclin D1 protein. No reaction wasobserved against other related cyclins. Cross-reacts with Human, Rat and Mouse. Not yet tested in other species. |
Application Details: Cyclin D1 (Human) antibody
| Application | Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB) |
| Application Notes | Suggested working dilutions *ELISA, immunofluorescence, Western Blot * Investigator should determine optimal working dilutions. This antibody can be used in ELISA, Western Blot, and Immunofluorescent Microscopy. Recommended Starting Dilutions*: WB: 1/500-1/1000ELISA: 1/500-1/2,000IF: End User must optimize*Optimal dilutions should be determined by the end user. * Other applications have not been tested. |
| Buffer | Serum containing 0.01% sodium azide 0.1 mg purified antisera. |
| Storage | Store vial at -20 degrees C or below prior to opening. Dilute only prior to immediate use.Aliquot contents and freeze at -20 degrees C or below. Avoid cycles of freezing andthawing. |
| Research Area | Cell Cycle |
| Restrictions | For Research Use only |
Product variants
| Cyclin D1 (Human) antibody (Format: Supernatant, Quantity: 0.5 ml) |
| Cyclin D1 (Human) antibody (Quantity: 0.1 ml) |
| Cyclin D1 (Human) antibody (Format: Purified, Quantity: 1 ml) |
External Information: Cyclin D1 (Human) antibody
| Google Scholar | Find more references for antigen Cyclin D1 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen Cyclin D1 (Bioinformatic Harvester (EMBL)) |
browse antibodies by
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
