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Product details for Cytokeratin 10 (Human) antibody
Cytokeratin 10 (Human) antibody
Overview
| Antigen: | Cytokeratin 10 |
| Antibody Type: | Monoclonal |
| Application: | Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB) |
| Reactivity: | Human, Dog (Canine) |
| Host: | Mouse |
| Quantity: | |
| Price: | 474,46 $ (Plus shipping costs and VAT, Invoice in EUR) |
| Order number: | ABIN145383 |
| Availability: | 7 to 10 days until shipment |
Additional Information: Cytokeratin 10 (Human) antibody
| Antigen | Cytokeratin 10 |
| Immunogen | Cytoskeletal preparation extracted from human epidermis |
| Reactivity | Human, Dog (Canine) |
| Antibody Type | Monoclonal |
| Format | Liquid |
| Isotype | IgG1 »Matching secondary antibodies |
| Description | Cytokeratin 10 is a heterotetramer of two type I and two type II keratins. Cytokeratin 10 is generally associated with keratin 1. It is seen in all suprabasal cell layers including stratum corneum. A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560). Defects in cytokeratin 10 are a cause of epidermolytic hyperkeratosis (EHK), also known as bullous congenital ichthyosiform erythroderma (BCIE) or bullous erythroderma ichthyosiformis congenita of Brocq. EHK is an hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum. At birth, affected individuals usually present with redness, blisters and superficial erosions due to cytolysis. Within a few weeks, the erythroderma and blister formation diminish and hyperkeratoses develop. Transmission is autosomal dominant, but most cases are sporadic. Defects in cytokeratin 10 are also a cause of annular epidermolytic ichthyosis (AEI), also known as cyclic ichthyosis |
| Clone | DE-K10 |
| Host | Mouse |
| Specificity | Reacts with keratinizing stratified epithelia and in differentiated areas of highly differentiated squamous cell carcinomas. |
Application Details: Cytokeratin 10 (Human) antibody
| Application | Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB) |
| Application Notes | FACS: 1/100-1/200. ICC: Use at an assay dependent dilution. IHC-P: Use at an assay dependent dilution. IHC-Fr: Use at an assay dependent dilution. WB: 1/100-1/1000. |
| Concentration | 1 mg/ml |
| Purity | Protein G affinity purified. |
| Buffer | PBS containing 0.09% sodium azide |
| Restrictions | For research use only |
External Information: Cytokeratin 10 (Human) antibody
| Google Scholar | Find more references for clone DE-K10 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen Cytokein 10 (Bioinformatic Harvester (EMBL)) |
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