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Product details for D4-GDI (Human) antibody
D4-GDI (Human) antibody
Overview
| Antigen: | D4-GDI |
| Antibody Type: | Polyclonal |
| Application: | Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Rabbit |
| Quantity: | |
| Price: | 361,63 $ (Plus shipping costs , $13.59 dry ice fee and VAT, Invoice in EUR) |
| Order number: | ABIN130959 |
| Availability: | 7 to 10 days until shipment |
Additional Information: D4-GDI (Human) antibody
| Antigen | D4-GDI |
| Reactivity | Human |
| Antibody Type | Polyclonal |
| Isotype | IgG, Ig »Matching secondary antibodies |
| Description | D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28kD mature form of D4-GDI to give a 23kDa and 5kDa size fragment. The 23kDa fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms. |
| Host | Rabbit |
| Specificity | The antibody recognizes 28 kDa D4-GDI in human samples. Not tested in other species. |
Application Details: D4-GDI (Human) antibody
| Application | Western Blotting (WB) |
| Application Notes | The antibody can be used for Western blotting (1-2 µg/ml). However, the optimal conditions should be determined individually. |
| Buffer | Supplied as 100 µg (0.5 mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide. |
| Restrictions | For Research Use Only |
External Information: D4-GDI (Human) antibody
| Google Scholar | Find more references for antigen D4-GDI on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen D4-GDI (Bioinformatic Harvester (EMBL)) |
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