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Produktdetails für  DAP Kinase 1 (phospho S308) (Human) antibody

DAP Kinase 1 (phospho S308) (Human) antibody

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Antigen: DAP Kinase 1 (phospho S308)
Antikörper-Typ: Monoklonal
Applikation: Dot Blot (Dot), ELISA, Immunoprecipitation (IP)
Reaktivität: Human
Wirt: Mouse
Menge: 50 µl (2 mg/ml)
Preis: 271,00 €   (Zzgl. Versandkosten und MWSt)
Bestellnummer: ABIN146423
Verfügbarkeit: 7 to 10 days until shipment
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Produktbeschreibung:  DAP Kinase 1 (phospho S308) (Human) antibody

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Antigen DAP Kinase 1 (phospho S308)
Immunogen Synthetic peptide, corresponding to amino acids 303-312 (pSER308) of Human DAP Kinase 1.
Reaktivität Human
Antikörper-Typ Monoklonal
Format Liquid
Isotyp IgG1 »Passende Sekundärantikörper
Beschreibung Various apoptotic signals use Death Associated Protein Kinase (DAPK) as a downstream effector in different cell types. DAPK is a positive mediator of apoptosis and is widely expressed in many tissues of embryonic and adult origin. DAPK is a Ca2+/calmodulin dependent Ser/Thr kinase that associates with microfilaments. The protein is composed of a multidomain structure. It has a subdomain typical of serine/threonine kinases, a Ca2+/calmodulin regulatory domain, eight ankyrin repeats followed by two P-loop motifs and a typical death domain module. It contains two auto-inhibitory domains one of them Ca2+/calmodulin dependent. In the absence of this latter domain, DAPK is constitutively active. DAPK activity is also regulated by phosphorylation. DAPK was found to be negatively regulated by autophosphorylation at Ser308 which is in the calmodulin regulatory domain. This autophosphorylation, which occurs in cells at the basal state, lowers the affinity of DAPK for calmodulin and thus the k
Klon DKPS308
Wirt Mouse

Anwendungen:  DAP Kinase 1 (phospho S308) (Human) antibody

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Applikation Dot Blot (Dot), ELISA, Immunoprecipitation (IP)
Applikationshinweise Dot: Use at a concentration of 1-2 ug/ml, Determined by immunoblotting using 293T (human embryonal kidney) cells transfected with DAPKinase expression vector. ELISA: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Konzentration 2 mg/ml
Reinheit Immunogen affinity purified
Buffer Preservative: 15mM Sodium AzideConstituents: 0.01mM PBS. pH 7.4
Beschränkungen For research use only

Weitere Informationen:  DAP Kinase 1 (phospho S308) (Human) antibody

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