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Détail du produit pour DAP Kinase 1 (phospho S308) (Human) antibody
DAP Kinase 1 (phospho S308) (Human) antibody
Aperçu
| Antigène: | DAP Kinase 1 (phospho S308) |
| Type anticorps: | Monoclonal |
| Application: | Dot Blot (Dot), ELISA, Immunoprecipitation (IP) |
| Reactivité: | Human |
| Hôte: | Mouse |
| Quantité: | |
| Prix: | 271,00 € (Plus frais de livraison et TVA) |
| Numéro de commande: | ABIN146423 |
| Disponibilité: | 7 to 10 days until shipment |
Description du produit: DAP Kinase 1 (phospho S308) (Human) antibody
| Antigène | DAP Kinase 1 (phospho S308) |
| Immunogène | Synthetic peptide, corresponding to amino acids 303-312 (pSER308) of Human DAP Kinase 1. |
| Reactivité | Human |
| Type anticorps | Monoclonal |
| Format | Liquid |
| Isotype | IgG1 »Anticorps secondaires correspondants |
| Description | Various apoptotic signals use Death Associated Protein Kinase (DAPK) as a downstream effector in different cell types. DAPK is a positive mediator of apoptosis and is widely expressed in many tissues of embryonic and adult origin. DAPK is a Ca2+/calmodulin dependent Ser/Thr kinase that associates with microfilaments. The protein is composed of a multidomain structure. It has a subdomain typical of serine/threonine kinases, a Ca2+/calmodulin regulatory domain, eight ankyrin repeats followed by two P-loop motifs and a typical death domain module. It contains two auto-inhibitory domains one of them Ca2+/calmodulin dependent. In the absence of this latter domain, DAPK is constitutively active. DAPK activity is also regulated by phosphorylation. DAPK was found to be negatively regulated by autophosphorylation at Ser308 which is in the calmodulin regulatory domain. This autophosphorylation, which occurs in cells at the basal state, lowers the affinity of DAPK for calmodulin and thus the k |
| Clone | DKPS308 |
| Hôte | Mouse |
Applications: DAP Kinase 1 (phospho S308) (Human) antibody
| Application | Dot Blot (Dot), ELISA, Immunoprecipitation (IP) |
| Indications d'application | Dot: Use at a concentration of 1-2 ug/ml, Determined by immunoblotting using 293T (human embryonal kidney) cells transfected with DAPKinase expression vector. ELISA: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | 2 mg/ml |
| Pureté | Immunogen affinity purified |
| Buffer | Preservative: 15mM Sodium AzideConstituents: 0.01mM PBS. pH 7.4 |
| Restrictions | For research use only |
Informations supplémentaires: DAP Kinase 1 (phospho S308) (Human) antibody
| Google Scholar | Trouver des références supplémentaires pour clone DKPS308 sur Google Scholar™ |
| EMBL Harvester | Recherche humain, souris ou rat génome pour antigène DAP Kinase 1 (phospho S308) (Bioinformatic Harvester (EMBL)) |
