DAP Kinase 2 (Human) antibody

Overview

Antigen:	DAP Kinase 2
Antibody Type:	Polyclonal
Application:	Western Blotting (WB)
Reactivity:	Human, Mouse (Murine), Rat
Host:	Rabbit
Quantity:	100 µg (0.5 mg/ml)
Price:	474,46 $ (Plus shipping costs and VAT, Invoice in EUR)
Order number:	ABIN142737
Availability:	7 to 10 days until shipment

Antigen	DAP Kinase 2
Immunogen	Peptide (ARRKALHPRRRSSTS) corresponding to aminoacids 356 to 370 of human DAPK2 (1,2).The sequence ofthis antigenic peptide is identical to the correspondingamino acids of mouse origin (1,2)
Reactivity	Human, Mouse (Murine), Rat
Antibody Type	Polyclonal
Format	Liquid
Isotype	IgG »Matching secondary antibodies
Description	Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is pro-apoptotic calcium-regulated serine/threonine kinase-containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFNg induced apoptosis. A novel DAP kinase-related protein was recently identified and designated DAPK2 and DRP-1 (1, 2). Ectopicly expressed DAPK2 induced apoptosis in various types of cells (1,2). DAPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA ofDAPK2 is expressed in multiple human tissues (1).
Host	Rabbit
Specificity	Does not react with DAPK1.

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EMBL Harvester	Search human, mouse or rat genome for antigen DAP Kinase 2 (Bioinformatic Harvester (EMBL))