DAP12 (Human) antibody

Overview

Antigen:	DAP12
Antibody Type:	Polyclonal
Application:	Western Blotting (WB)
Reactivity:	Human
Host:	Rabbit
Quantity:	100 µg
Price:	327,64 $ (Plus shipping costs , $13.59 dry ice fee and VAT, Invoice in EUR)
Order number:	ABIN131484
Availability:	7 to 10 days until shipment

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Additional Information: DAP12 (Human) antibody

Antigen	DAP12
Immunogen	The immunogen was a recombinant peptide corresponding to amino acid residues 28-40 of human DAP12, expressed in E. coli.
Reactivity	Human
Antibody Type	Polyclonal
Isotype	IgG, Ig »Matching secondary antibodies
Description	DAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is present as a disulphide-bonded homodimer. Cross-linking of DAP 12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation.
Host	Rabbit
Specificity	Recognizes DAP12 in human cell lysates.

Application Details: DAP12 (Human) antibody

Application	Western Blotting (WB)
Application Notes	The antibody can be used for Western blot analysis (1 µg/ml). However, the optimal conditions should be determined individually.
Buffer	Supplied as 100 µg (0.5 mg/ml) purified rabbit anti-human DAP12 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.
Restrictions	For Research Use Only

Publications: DAP12 (Human) antibody

Publications

Lanier, Corliss, Wu et al.:
"Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells."
In: Nature , Vol. 391, Issue 6668, pp. 703-7, 1998/01 (PubMed)

Tomasello, Olcese, Vely et al.:
"Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12."
In: The Journal of biological chemistry , Vol. 273, Issue 51, pp. 34115-9, 1999/01 (PubMed)

External Information: DAP12 (Human) antibody

Google Scholar	Find more references for antigen DAP12 on Google Scholar™
EMBL Harvester	Search human, mouse or rat genome for antigen DAP12 (Bioinformatic Harvester (EMBL))