DAP3 (Human) antibody

Overview

Antigen:	DAP3
Antibody Type:	Polyclonal
Application:	Western Blotting (WB)
Reactivity:	Human
Host:	Rabbit
Quantity:	100 µg
Price:	361,63 $ (Plus shipping costs , $13.59 dry ice fee and VAT, Invoice in EUR)
Order number:	ABIN130461
Availability:	7 to 10 days until shipment

Hints on ordering

Add to basket

Customer Service

Technical Inquiry
Send product details to colleague
Download Datasheet

Additional Information: DAP3 (Human) antibody

Antigen	DAP3
Reactivity	Human
Antibody Type	Polyclonal
Format	Liquid
Isotype	IgG, Ig »Matching secondary antibodies
Description	Death Associated Protein 3 (DAP3) is a 46 kDa protein carrying a potential nucleotide binding motif (P-loop) at its N-terminal region. The protein is widely expressed, and the expression is up-regulated during membrane-receptor mediated apoptosis. In interferon-. and Fas induced apoptosis, DAP3 acts as a positive mediator by functioning downstream of the receptor signaling complex and upstream of the effector caspases. However, the mechanism for its function is largely unknown. Interestingly, the N-terminal 230 amino acid fragment of DAP3 alone protects cells from Fas induced cell death. The same region of DAP3 also serves as a binding site for the glucocorticoid receptor and mediates receptor functions.
Host	Rabbit
Specificity	The antibody detects 46 kDa human DAP3. It does not cross-react with other DAP family members.

Application Details: DAP3 (Human) antibody

Application	Western Blotting (WB)
Application Notes	Suitable for use in Western blotting analysis (1 - 2 µg/ml).
Buffer	Supplied as 100 µg (0.2 mg/ml) affinity-purified rabbit anti-DAP3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.
Restrictions	For Research Use Only

Publications: DAP3 (Human) antibody

Publications

Hulkko, Wakui, Zilliacus:
"The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function."
In: The Biochemical journal , Vol. 349 Pt 3, pp. 885-93, 2001/01 (PubMed)

Kissil, Deiss, Bayewitch et al.:
"Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death."
In: The Journal of biological chemistry , Vol. 270, Issue 46, pp. 27932-6, 1996/01 (PubMed)

External Information: DAP3 (Human) antibody

Google Scholar	Find more references for antigen DAP3 on Google Scholar™
EMBL Harvester	Search human, mouse or rat genome for antigen DAP3 (Bioinformatic Harvester (EMBL))