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Product details for DAP3 (Human) antibody
DAP3 (Human) antibody
Overview
| Antigen: | DAP3 |
| Antibody Type: | Monoclonal |
| Application: | Western Blotting (WB) |
| Reactivity: | Human, Mouse (Murine) |
| Host: | Mouse |
| Quantity: | |
| Price: | 342,59 $ (Plus shipping costs and VAT, Invoice in EUR) |
| Order number: | ABIN145334 |
| Availability: | 7 to 10 days until shipment |
Additional Information: DAP3 (Human) antibody
| Antigen | DAP3 |
| Immunogen | Synthetic peptide: PRAISRTNQYYLENNWLQHEKA, corresponding to amino acids 45-52 and 358-371 of Human DAP3. |
| Reactivity | Human, Mouse (Murine) |
| Antibody Type | Monoclonal |
| Format | Liquid |
| Isotype | IgG1 »Matching secondary antibodies |
| Description | Death Associated Protein 3 (DAP 3) is a 46 kDa protein carrying a potential nucleotide binding motif (P-loop) at its N-terminal region. The protein is widely expressed, and the expression is upregulated during membrane-receptor mediated apoptosis. In interferon-gamma and Fas induced apoptosis, DAP 3 acts as a positive mediator by functioning downstream of the receptor signaling complex and upstream of the effector caspases. However, the mechanism for its function is largely unknown. Interestingly, the N-terminal 230 amino acid fragment of DAP 3 alone protects cells from Fas induced cell death. The same region of DAP 3 also serves as a binding site for the glucocorticoid receptor and mediates receptor functions. |
| Clone | 42C617 |
| Host | Mouse |
Application Details: DAP3 (Human) antibody
| Application | Western Blotting (WB) |
| Application Notes | WB: Use at a concentration of 1-2 ug/ml. Detects a band of approximately 45 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | 0.5 mg/ml |
| Purity | Immunogen affinity purified |
| Buffer | Preservative: 0.02% Sodium AzideConstituents: PBS |
| Storage | Store at 4 C. Aliquot and store at -20 C long-term. |
| Restrictions | For research use only |
External Information: DAP3 (Human) antibody
| Google Scholar | Find more references for clone 42C617 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen DAP3 (Bioinformatic Harvester (EMBL)) |
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