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Product details for  DAP3 (Human) antibody
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DAP3 (Human) antibody

Overview

Antigen: DAP3
Antibody Type: Polyclonal
Application: Western Blotting (WB)
Reactivity: Human
Host: Rabbit
Quantity: 50 µg (0.2 mg/ml) (Product variants)
Price: 335,80 $   (Plus shipping costs and VAT, Invoice in EUR)
Order number: ABIN150549
Availability: 7 to 10 days until shipment
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Additional Information:  DAP3 (Human) antibody

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Antigen DAP3
Immunogen Available on request.
Reactivity Human
Antibody Type Polyclonal
Isotype IgG »Matching secondary antibodies
Description Death Associated Protein 3 (DAP 3) is a 46 kDa protein carrying a potential nucleotide binding motif (P-loop) at its N-terminal region. The protein is widely expressed, and the expression is upregulated during membrane-receptor mediated apoptosis. In interferon-gamma and Fas induced apoptosis, DAP 3 acts as a positive mediator by functioning downstream of the receptor signaling complex and upstream of the effector caspases. However, the mechanism for its function is largely unknown. Interestingly, the N-terminal 230 amino acid fragment of DAP 3 alone protects cells from Fas induced cell death. The same region of DAP 3 also serves as a binding site for the glucocorticoid receptor and mediates receptor functions.
Host Rabbit
Specificity This antibody recognizes the 46 kDa human DAP 3. It does not cross-react with other DAP family members.

Application Details:  DAP3 (Human) antibody

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Application Western Blotting (WB)
Application Notes WB: Use at a concentration of 1-2 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Concentration 0.2 mg/ml
Purity Immunogen affinity purified
Buffer PBS pH7.2 with 50% glycerol, 1% BSA and 0.02% sodium azide
Storage Store at -20 C. For long term storage, aliquot and refreeze at -70 C. Avoid repeated freeze/defrost cycles
Restrictions For research use only

Publications:  DAP3 (Human) antibody

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Publications Hulkko, Wakui, Zilliacus:
"The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function."
In: The Biochemical journal , Vol. 349 Pt 3, pp. 885-93, 2001/01 (PubMed)

Tan, Nuttall:
"Characteristics of the dephosphorylated form of phosphorylase purified from rat liver and measurement of its activity in crude liver preparations."
In: Biochimica et biophysica acta , Vol. 410, Issue 1, pp. 45-60, 1976/01 (PubMed)

External Information:  DAP3 (Human) antibody

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Google Scholar Find more references for antigen DAP3 on Google Scholar™
EMBL Harvester Search human, mouse or rat genome for antigen DAP3 (Bioinformatic Harvester (EMBL))