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Product details for DARPP-32 (Human) antibody
DARPP-32 (Human) antibody
Overview
| Antigen: | DARPP-32 |
| Antibody Type: | Polyclonal |
| Application: | Western Blotting (WB) |
| Reactivity: | Human, Mouse (Murine), Rat |
| Host: | Rabbit |
| Quantity: | |
| Price: | 361,63 $ (Plus shipping costs , $13.59 dry ice fee and VAT, Invoice in EUR) |
| Order number: | ABIN130960 |
| Availability: | 7 to 10 days until shipment |
Additional Information: DARPP-32 (Human) antibody
| Antigen | DARPP-32 |
| Reactivity | Human, Mouse (Murine), Rat |
| Antibody Type | Polyclonal |
| Isotype | IgG, Ig »Matching secondary antibodies |
| Description | DARPP-32 (dopamine and cyclic AMP-regulated phosphoprotein) is a cytosolic protein highly enriched spiny neurons of the neostriatum. DARPP-32 is a bifunctional signal transduction molecule that controls serine/threonine kinase and serine/threonine phosphatase activity depending on the phosphorylation state of the protein. Dopamine stimulates phosphorylation of DARPP-32 through D1 receptors and activation of PKA. PKA phosphorylation of DARPP-32 at threonine 34 converts it into an inhibitor of protein phosphatase 1. DARPP-32 is converted into an inhibitor of PKA when phosphorylated at threonine 75 by cyclin-dependent kinase 5 (cdk5). Mice containing a targeted deletion of the DARPP-32 gene exhibit an altered biochemical, electrophysiological and behavioral phenotype. |
| Host | Rabbit |
| Specificity | The antibody recognizes 32 kDa DARPP-32 of human, mouse, and rat origins. |
Application Details: DARPP-32 (Human) antibody
| Application | Western Blotting (WB) |
| Application Notes | The antibody can be used for Western blot analysis (1-2 µg/ml). However, the optimal conditions should be determined individually. |
| Buffer | 100 µg (0.5mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide. |
| Restrictions | For Research Use Only |
External Information: DARPP-32 (Human) antibody
| Google Scholar | Find more references for antigen DARPP-32 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen DARPP-32 (Bioinformatic Harvester (EMBL)) |
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