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Détail du produit pour DARPP-32 pSer75 (Human) antibody
DARPP-32 pSer75 (Human) antibody
Aperçu
| Antigène: | DARPP-32 pSer75 |
| Type anticorps: | Polyclonal |
| Application: | Western Blotting (WB) |
| Reactivité: | Human, Mouse (Murine) |
| Hôte: | Rabbit |
| Quantité: | |
| Prix: | 330,00 € (Plus frais de livraison et TVA) |
| Numéro de commande: | ABIN152574 |
| Disponibilité: | Ships in 7 to 10 days |
Description du produit: DARPP-32 pSer75 (Human) antibody
| Antigène | DARPP-32 pSer75 |
| Immunogène | Synthetic phosphopeptide corresponding to amino acids residues surrounding thephospho Thr75 of DARPP-32. The sequence of the immunogen is identical in humanand mouse. |
| Reactivité | Human, Mouse (Murine) |
| Type anticorps | Polyclonal |
| Format | Aff - Purified |
| Description | DARPP-32, a dopamine (DA) and cAMP-regulated ~32k phosphoprotein, is associatedwith dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The proteininhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, whenDARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP is thought to play a critical role in the regulation ofdopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thoughtto play important roles in the actions of alcohol, caffeine and Prozac®. |
| Hôte | Rabbit |
| Specificité | Specific for the ~34k DARPP-32 phosphorylated at Thr75. This antibody recognizes human, mouse, and rat forms of the protein. Other specieshave not been tested. |
Applications: DARPP-32 pSer75 (Human) antibody
| Application | Western Blotting (WB) |
| Indications d'application | Western and Dot blots. Suggested working dilutions: *Immunoblot - 1:1,000Immunohistochemistry - ND*The investigator should determine the optimal working dilution for a specific application. |
| Buffer | 0.1 ml affinity purified antibody in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mlBSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blot. |
| Stock | For long term storage –80 degrees Celcius is recommended, but shorter term storage at–20 degrees Celcius is also acceptable as aliquots may be taken without freeze/thawingdue to the presence of 50% glycerol. |
| Restrictions | For Research Use only |
Informations supplémentaires: DARPP-32 pSer75 (Human) antibody
| Google Scholar | Trouver des références supplémentaires pour antigène DARPP-32 pSer75 sur Google Scholar™ |
| EMBL Harvester | Recherche humain, souris ou rat génome pour antigène DARPP-32 pSer75 (Bioinformatic Harvester (EMBL)) |
