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Product details for DARPP-32 pThr34 (Human) antibody
DARPP-32 pThr34 (Human) antibody
Overview
| Antigen: | DARPP-32 pThr34 |
| Antibody Type: | Polyclonal |
| Application: | Western Blotting (WB) |
| Reactivity: | Human, Mouse (Murine), Rat |
| Host: | Rabbit |
| Quantity: | |
| Price: | 475,82 $ (Plus shipping costs and VAT, Invoice in EUR) |
| Order number: | ABIN152564 |
| Availability: | Ships in 7 to 10 days |
Additional Information: DARPP-32 pThr34 (Human) antibody
| Antigen | DARPP-32 pThr34 |
| Immunogen | The immunogen used to generate our antibody was a synthetic phosphopeptidecorresponding to amino acid residues surrounding the phospho Thr34 of DARPP-32. |
| Reactivity | Human, Mouse (Murine), Rat |
| Antibody Type | Polyclonal |
| Format | Aff - Purified |
| Description | DARPP-32, a dopamine (DA) and cAMP-regulated ~32k phosphoprotein, is associatedwith dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The proteininhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, whenDARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP-32 is thought to play a critical role in the regulation ofdopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thoughtto play important roles in the actions of alcohol, caffeine and Prozac®. |
| Host | Rabbit |
| Specificity | ABIN152564 reacts with human, mouse, and rat forms of the protein. |
Application Details: DARPP-32 pThr34 (Human) antibody
| Application | Western Blotting (WB) |
| Application Notes | NB 300-224 can be used in Western and Dot blot experiments. Immunohistochemostryapplications have not been determined. Suggested working dilutions: *Immunoblot - 1:1,000*The investigator should determine the optimalworking dilution for a specific application. |
| Buffer | 0.1 ml of affinity purified antisera in 10mM HEPES (pH 7.5), 150 mM NaCl, 100 ug/ml BSA and 50% glycerol. Enough for 10-mini blots. |
| Storage | Store at -20 degrees Celcius for 1 year. Aliquot and store at –80 degrees Celcius forlong-term storage. |
| Restrictions | For Research Use only |
External Information: DARPP-32 pThr34 (Human) antibody
| Google Scholar | Find more references for antigen DARPP-32 pThr34 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen DARPP-32 pThr34 (Bioinformatic Harvester (EMBL)) |
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