DEDAF (Human) antibody

Overview

Antigen:	DEDAF
Antibody Type:	Polyclonal
Application:	Western Blotting (WB)
Reactivity:	Human, Mouse (Murine), Rat
Host:	Rabbit
Quantity:	100 µg
Price:	361,63 $ (Plus shipping costs , $13.59 dry ice fee and VAT, Invoice in EUR)
Order number:	ABIN130899
Availability:	7 to 10 days until shipment

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Additional Information: DEDAF (Human) antibody

Antigen	DEDAF
Reactivity	Human, Mouse (Murine), Rat
Antibody Type	Polyclonal
Isotype	IgG, Ig »Matching secondary antibodies
Description	Cell death signal are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. A novel protein that interacts with DED of caspase-8 and -10, and FADD was recently identified and designated DEDAF (for DED associated factor). DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/caspase-8 complexes at the cytoplasm. DEDAF also interacts with DED-containing DNA biding protein (DEDD) in the nucleus, indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.
Host	Rabbit
Specificity	The antibody detects the ~32 kDa DEDAF in human, mouse, and rat. A549 or HepG2 cell lysates can be used as a positive control.

Application Details: DEDAF (Human) antibody

Application	Western Blotting (WB)
Application Notes	The antibody can be used for Western blot analysis (1 µg/ml). However, the optimal conditions should be determined individually.
Buffer	Supplied as 100 µg (0.5 mg/ml) affinity purified rabbit anti-DEDAF polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.
Restrictions	For Research Use Only

Publications: DEDAF (Human) antibody

Publications

Inbal, Shani, Cohen et al.:
"Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis."
In: Molecular and cellular biology , Vol. 20, Issue 3, pp. 1044-54, 2000/01 (PubMed)

Kawai, Nomura, Hoshino et al.:
"Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity."
In: Oncogene , Vol. 18, Issue 23, pp. 3471-80, 1999/01 (PubMed)

External Information: DEDAF (Human) antibody

Google Scholar	Find more references for antigen DEDAF on Google Scholar™
EMBL Harvester	Search human, mouse or rat genome for antigen DEDAF (Bioinformatic Harvester (EMBL))