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Antigen
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DIAPH2
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Immunogen
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Synthetic peptide: VPLERSRSRHNGAISSK conjugated to KLH, corresponding to aminoacids 1085-1101 of Human DIA. Epitope: aa 1085-1101
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Reactivity
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Human
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Antibody Type
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Polyclonal
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Format
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Aff - Purified
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Description
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DIA-2 (also called DIAdrome, Dia2, DIAPH2, Diaphanous 2, Diaphanousrelated formin 2, Diaphorase 2, DRF2, POF and POF2)may play a role in the development and normal functionof the ovaries. Mutations of this gene have been linkedto premature ovarian failure. Alternative splicing resultsin two protein isoforms. Furthermore, each splicevariant undergoes additional splicing in the 3', UTR.Overall 4 splice variants have been described. DIA-2 isexpressed in testis, ovary, small intestine, prostate,lung, liver, kidney and leukocytes and can be foundfrom E16 in ovary and testis and during P6-P16 duringdifferentiation of ovarian follicles. Isoform 1 is referredto as DIA-156, whereas isoform 2 is called DIA-12C. Synonyms: DIA antibody, Dia drome antibody, Dia2 antibody, Diap2 antibody, DIAPH2 antibody,Diaphanous 2 antibody, Diaphanous related formin 2 antibody, Diaphorase 2 antibody,DRF2 antibody, POF antibody, POF2 antibody
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Host
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Rabbit
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Specificity
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This antibody detects a band at 130kD in HEK293 cells representing DIA2. Cross-reacts with Human. Expected to cross-react with Mouse (93% identity withimmunogen) due to sequence homology. Not yet tested in other species.
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