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Product details for DcR1 (TRAIL-R3) Human antibody
DcR1 (TRAIL-R3) Human antibody
Overview
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| Antigen: | DcR1 (TRAIL-R3) |
| Antibody Type: | Monoclonal |
| Application: | Flow Cytometry (FACS) |
| Conjugate: | PE |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 180,81 $ (Plus shipping costs and VAT, Invoice in EUR) |
| Order number: | ABIN158335 |
| Availability: | Ships within 7 to 10 days |
Additional Information: DcR1 (TRAIL-R3) Human antibody
| Antigen | DcR1 (TRAIL-R3) |
| Immunogen | Extracellular domain of DcR1-human IgG1 Fc fusion |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Isotype | Mouse IgG1, kappa »Matching secondary antibodies |
| Description | DcR1 is a 65 kD GPI-anchored member of the TNFR superfamily (TNFRSF10C) also known as TRAIL-R3, TRID, CD263, and LIT. Although not expressed by most tumors, DcR1 is expressed at low levels on normal tissues, acting as a TRAIL decoy receptor, thus inhibiting apoptosis. DcR1 is termed a decoy receptor, as it does not have a functional death domain to induce apoptosis following TRAIL ligation. Distribution: Most normal tissues, not tumors Function: TRAIL decoy, inhibits apoptosis Synonyms: TRAIL-R3, TRID, LIT, CD263, TNFRSF10C Structure: TNFR superfamily, GPI-anchored, truncated death domain, 65 kD |
| Clone | DJR3 |
| Host | Mouse |
Application Details: DcR1 (TRAIL-R3) Human antibody
| Application | Flow Cytometry (FACS) |
| Application Notes | Additional reported applications (for the relevant formats) include: The DJR3 antibody is useful for immunofluorescent staining and flow cytometric analysis of DcR1/TRAIL-R3 receptor expression. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (ABIN158336) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody (ABIN158334) or biotinylated anti-mouse IgG second step (ABIN159908), followed by SAv-PE (ABIN159899)). Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 µl per million cells or 20 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Conjugate | PE |
| Purification | The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody. |
| Buffer | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA). |
| Storage | The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Research Area | Signaling, Apoptosis/Necrosis |
| Restrictions | For Research Use only |
Publications: DcR1 (TRAIL-R3) Human antibody
| Publications |
Pan, Ni, Wei et al.: "An antagonist decoy receptor and a death domain-containing receptor for TRAIL." In: Science (New York, N.Y.) , Vol. 277, Issue 5327, pp. 815-8, 1997/01 (PubMed) Sato, Nakaoka, Yamashita et al.: "TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapse." In: Journal of immunology (Baltimore, Md. : 1950) , Vol. 174, Issue 7, pp. 4025-33, 2005/01 (PubMed) Uno, Inukai, Kayagaki et al.: "TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells." In: Blood , Vol. 101, Issue 9, pp. 3658-67, 2003/01 (PubMed) MacFarlane, Ahmad, Srinivasula et al.: "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL." In: The Journal of biological chemistry , Vol. 272, Issue 41, pp. 25417-20, 1997/01 (PubMed) |
Images: DcR1 (TRAIL-R3) Human antibody
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Human peripheral blood granulocytes stained with DJR3 PE |
Product variants
External Information: DcR1 (TRAIL-R3) Human antibody
| Google Scholar | Find more references for clone DJR3 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen DcR1 (TRAIL-R3) (Bioinformatic Harvester (EMBL)) |
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