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Product details for Defensin 2, beta- (Human) antibody
Defensin 2, beta- (Human) antibody
Overview
| Antigen: | Defensin 2, beta- |
| Antibody Type: | Polyclonal |
| Host: | Rabbit |
| Quantity: | |
| Price: | 492,48 $ (Plus shipping costs and VAT, Invoice in EUR) |
| Order number: | ABIN98285 |
| Availability: | 7 days until shipment |
Additional Information: Defensin 2, beta- (Human) antibody
| Antigen | Defensin 2, beta- |
| Immunogen | 3 different peptides (14 aa from human BD-2, 14-aa from rat defensin-2, and 17 aa from mouse BD-2 (the mixture designated as designated HBD21-P, control peptides) near the N-terminus of mature BD-2 conjugated to KLH |
| Antibody Type | Polyclonal |
| Format | Ig Fraction |
| Description | Antimicrobial peptides are a common mechanism of host defense utilized by a variety of species, from insects to humans. Defensins are a large family of broad-spectrum antimicrobial peptides, identified originally in leukocytes of rabbits and humans. Defensins, cationic/polar peptides (30-35 aa, 3-4 kDa), are distinguished by a conserved tri-disulfides and a largely b-Sheet structure. Defensins, expressed at the cell surface, have been hypothesized to function as a biochemical barrier against microbial infection by inhibiting colonization of the epithelium by wide range of pathogenic microorganisms. The genes encoding human ? and ? -defensins are clustered in a contiguous segment of chromosome 8p23. Defensins are classified into two families designated ? ? and ? - based on distinctive, although similar, tri-disulfide linkages in the peptides. b-defensins are slightly larger and differ in the position and arrangement of 3 disulfides. In humans, six ? ?defensin (cryptidins), HD 1-6 |
| Host | Rabbit |
| Specificity | The beta-defensin-2 peptides selected for antibody production have no significant sequence homology with other defensins. Antibody HBD21 reacts with HBD-2 from mouse, rat, and human beta defensin-2. Antibody cross-reactivity in various other species has |
Application Details: Defensin 2, beta- (Human) antibody
| Research Area | Immunology |
| Restrictions | For Research Use only |
Publications: Defensin 2, beta- (Human) antibody
| Publications |
Wang TT et al: "Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression" In: J Immunol , Vol. 173(5), pp. 2909-12, 2004/01 (PubMed) Fahlgren A et al: "Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis." In: Clin Exp Immunol , Vol. 131(1), pp. 90-101, 2003/01 (PubMed) Wade BK, Burrus JK, Balkovetz DF: "Hepatocyte growth factor inhibits intrinsic antibacterial activity of Madin-Darby canine kidney cells" In: Microbes Infect. , Vol. 6(1), pp. 51-7, 2004/01 (PubMed) |
External Information: Defensin 2, beta- (Human) antibody
| Google Scholar | Find more references for antigen Defensin 2, beta- on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen Defensin 2, beta- (Bioinformatic Harvester (EMBL)) |
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