Endothelin-1 antibody

Overview

Antigen	Endothelin-1
Immunogen	Synthetic peptide of a part of ET-1 (Common parts with Human, Bovine, Canine, Mouse, Porcine, and Rat)
Antibody Type	Monoclonal
Isotype	IgG2b »Matching secondary antibodies
Description	Endothelins are 21 amino acid peptides that are produced ubiquitously by vascular endothelial cells, smooth muscle cells, and other cells in different organs. Endothelins are secreted as big-endothelins that are converted to active proteins by the endothelin-converting enzyme. These peptides possess many biological activities, such as vasoconstriction and mitogenesis, and are involved in numerous physiological and pathophysiological processes in humans. Elevated plasma levels of endothelin have been associated with heart failure, and increased immunoreactivity for endothelin is observed in transplant coronary artery disease. Endothelin-1 (ET-1) is known as the most potent vasoconstrictor substance.
Clone	9H
Host	Mouse
Specificity	Endothelin-1 100.0 % Endothelin-2 100.0 % Endothelin-3 100.0 % Big Endothelin-1 100.0 % Big Endothelin-2 100.0 % Big Endothelin-3 100.0 % VIC 100.0 % No crossreactivities with Endothelin(15-21)

Application	ELISA
Application Notes	ELISA
Purification	Protein A
Buffer	Lyophilized product from 1% BSA in PBS . Reconstitution: 1 ml distilled water will be added to the product
Storage	Lyophilized product, 5 years at 2 8 : Solution, 2 years at 20
Research Area	Hormones
Restrictions	For Research Use only

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EMBL Harvester	Search human, mouse or rat genome for antigen Endothelin-1 (Bioinformatic Harvester (EMBL))