Endothelin-1 antibody

Overview

Antigen	Endothelin-1
Immunogen	Synthetic peptide of a part of ET-1 (A common parts of Bovine, Canine, Human, Mouse, Porcine and Rat) Purification: Affinity Purified with synthetic peptides Absorbed by ET-3 peptides
Antibody Type	Polyclonal
Isotype	IgG »Matching secondary antibodies
Description	Endothelins are 21 amino acid peptides that are produced ubiquitously by vascular endothelial cells, smooth muscle cells, and other cells in different organs. Endothelins are secreted as big-endothelins that are converted to active proteins by the endothelin-converting enzyme. These peptides possess many biological activities, such as vasoconstriction and mitogenesis, and are involved in numerous physiological and pathophysiological processes in humans. Elevated plasma levels of endothelin have been associated with heart failure, and increased immunoreactivity for endothelin is observed in transplant coronary artery disease.
Host	Rabbit
Specificity	Endothelin-1 100.0% Endothelin-2 1.0% Endothelin-3 0.4% Big Endothelin-1 100.0% Big Endothelin-2 0.2% Big Endothelin-3 0.4% VIC 0.2%

Application	Immunohistochemistry (IHC)
Application Notes	This antibody can be stained in formalin fixed paraffin embedded tissues by Immunohistochemical techniques such as SAB Method. The optimal dilution is 3-5 ug/ml, however, the dilution rate should be optimized by each laboratories.
Purification	Antigen peptide ET-3 absorbed
Buffer	Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1.0 ml distilled water will be added to the product
Storage	Lyophilized product, 5 years at 2 8 : Solution, 2 years at 20
Restrictions	For Research Use only

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