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Product details for ErbB2 (Human) antibody
ErbB2 (Human) antibody
Overview
| Antigen: | ErbB2 |
| Antibody Type: | Monoclonal |
| Application: | Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Rat |
| Quantity: | |
| Price: | 335,80 $ (Plus shipping costs and VAT, Invoice in EUR) |
| Order number: | ABIN145639 |
| Availability: | 7 to 10 days until shipment |
Additional Information: ErbB2 (Human) antibody
| Antigen | ErbB2 |
| Immunogen | Recombinant full length protein (Human). |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Format | Liquid |
| Isotype | IgG2a »Matching secondary antibodies |
| Description | ErbB2 (also known as Her2 or neu) is a 185 kDa transmembrane receptor tyrosine kinase from the EGFR family that acts to regulate a variety of biological responses including cell growth, differentiation, and tissue development. Ligand binding to the extracellular domain, or overexpression of the receptor leads to phosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Overexpression or abnormal activation of ErbB2 has been found in a variety of tumors including brain, breast, lung and skin cancer. Autophosphorylation of tyrosine 1139 on ErbB2 allows binding of Grb2 and the Src SH2 domain, which allows activation of the Ras, Raf, ERK1&2 and JAK/STAT signaling pathways, respectively. |
| Clone | ICR55 |
| Host | Rat |
Application Details: ErbB2 (Human) antibody
| Application | Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB) |
| Application Notes | IHC-P: Use at an assay dependent dilution. Antigen retrieval is not essential but may optimise staining. IHC-Fr: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 77 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | 1 mg/ml |
| Purity | IgG fraction |
| Buffer | Preservative: 0.02% Sodium AzideConstituents: PBS |
| Storage | Store at 4 C. Aliquot and store at -20 C long-term. |
| Restrictions | For research use only |
External Information: ErbB2 (Human) antibody
| Google Scholar | Find more references for clone ICR55 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen ErbB2 (Bioinformatic Harvester (EMBL)) |
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