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Product details for Herstatin (Human) antibody
Herstatin (Human) antibody
Overview
| Antigen: | Herstatin |
| Antibody Type: | Monoclonal |
| Application: | ELISA, Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 441,84 $ (Plus shipping costs and VAT, Invoice in EUR) |
| Order number: | ABIN108474 |
| Availability: | Ships in 4 to 9 days |
Additional Information: Herstatin (Human) antibody
| Antigen | Herstatin |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Format | Immunoaffinity Purified |
| Isotype | IgG2a »Matching secondary antibodies |
| Description | Specification: The monoclonal antibody clone: 2D4 reacts with an epitope located on undrerilined sequence of herstatin (Human Herstatin 79 ? last 79 amino acids of Human Herstatin). |
| Clone | 2D4 |
| Host | Mouse |
Application Details: Herstatin (Human) antibody
| Application | ELISA, Western Blotting (WB) |
| Application Notes | Titre: Is defined by indirect ELISA, it is >1/100,000 for antibody concentration 1mg/ml, 25 ng of antigen are coated per well, and is then defined at a point of maximal decrease of the titration curve. |
| Storage | Store lyophilized antibody at 2-8°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles and store frozen at -80°C. Reconstituted antibody can be stored at 4°C for a limited period of time, it does not show decline in activity after two weeks at 4°C. |
| Restrictions | For research use only |
Publications: Herstatin (Human) antibody
| Publications |
Jhabvala-Romero F, Evans A, Guo S et al.: "Herstatin inhibits heregulin-mediated breast cancer cell growth and overcomes tamoxifen resistance in breast cancer cells that overexpress HER-2." In: Oncogene , Vol. 22, Issue 50, pp. 8178-86, 2003/11 (PubMed) Azios NG, Romero FJ, Denton MC et al.: "Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF receptor." In: Oncogene , Vol. 20, Issue 37, pp. 5199-209, 2001/08 (PubMed) Doherty JK, Bond C, Jardim A et al.: "The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor." In: Proc Natl Acad Sci U S A , Vol. 96, Issue 19, pp. 10869-74, 1999/09 (PubMed) |
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