High Mobility Group 1 antibody

概述

抗原:	High Mobility Group 1
抗体类型:	多克隆抗体
应用范围:	Western Blotting (WB)
抗体来源:	Rabbit
规格:	125 µl
价格:	3.677,67 ¥ (加上运费和增值税, Invoice in EUR)
货号:	ABIN123797
发货时间:	Ships in 1 to 2 days.

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详细信息: High Mobility Group 1 antibody

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抗原	High Mobility Group 1
抗体类型	多克隆抗体
状态	Liquid. Supplied as high titer anti-serum.
描述	High mobility group 1 (HMG1) is a 26 k Da highly conserved non-sequence-specific DNA-binding nuclear protein. Mammalian HMG1 has two homologous DNA-binding domains HMG boxes, A and B (each of 80?90 amino-acid residues), linked by a short basic region to an acidic C-terminal domain containing 30 consecutive Asp and Glu residues. HMG1 has been implicated in a number of fundamental biological processes including transcription, replication and recombination, in which it plays a role in manipulating DNA structure by bending, looping, compaction or unwinding, or by direct contacts with distinct cellular proteins. HMG1 can act as a repressor, by interacting with TBP to block pre-initiation complex formation or as an activator, by facilitating the binding of various transcription factors to their cognate DNA sequences. Most recently, it was discovered that HMG1 is a late mediator of delayed endotoxin lethality by activating downstream cytok ine release.
抗体来源	Rabbit
特异性	Alpha-HMG1 reacts with the HMG1 protein in HeLa nuclear extract by Western blotting.

使用细节: High Mobility Group 1 antibody

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应用范围	Western Blotting (WB)
应用备注	Recommended dilution range for Western blot analysis: 1:2000 - 1:5000.
贮藏	Store at -80 °C, avoid freeze/thaw cycles. Shipped on dry ice. Shelf Life: 12 months.
限制	For Research Use only.

参考文献: High Mobility Group 1 antibody

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参考文献

Bianchi, Beltrame, Paonessa:
"Specific recognition of cruciform DNA by nuclear protein HMG1."
In: Science (New York, N.Y.) , Vol. 243, Issue 4894 Pt 1, pp. 1056-9, 1989/01 (PubMed)

Bustin, Lehn, Landsman:
"Structural features of the HMG chromosomal proteins and their genes."
In: Biochimica et biophysica acta , Vol. 1049, Issue 3, pp. 231-43, 1990/01 (PubMed)

Ge, Roeder:
"The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein."
In: The Journal of biological chemistry , Vol. 269, Issue 25, pp. 17136-40, 1994/01 (PubMed)

Jayaraman, Moorthy, Murthy et al.:
"High mobility group protein-1 (HMG-1) is a unique activator of p53."
In: Genes & development , Vol. 12, Issue 4, pp. 462-72, 1998/01 (PubMed)

Lu, Peterson, Dasgupta et al.:
"Influence of HMG-1 and adenovirus oncoprotein E1A on early stages of transcriptional preinitiation complex assembly."
In: The Journal of biological chemistry , Vol. 275, Issue 45, pp. 35006-12, 2000/01 (PubMed)

Onate, Prendergast, Wagner et al.:
"The DNA-bending protein HMG-1 enhances progesterone receptor binding to its target DNA sequences."
In: Molecular and cellular biology , Vol. 14, Issue 5, pp. 3376-91, 1994/01 (PubMed)

Stelzer, Goppelt, Lottspeich et al.:
"Repression of basal transcription by HMG2 is counteracted by TFIIH-associated factors in an ATP-dependent process."
In: Molecular and cellular biology , Vol. 14, Issue 7, pp. 4712-21, 1994/01 (PubMed)

Yang, Wang, Tracey:
"HMG-1 rediscovered as a cytokine."
In: Shock (Augusta, Ga.) , Vol. 15, Issue 4, pp. 247-53, 2001/01 (PubMed)

Zappavigna, Falciola, Helmer-Citterich et al.:
"HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation."
In: The EMBO journal , Vol. 15, Issue 18, pp. 4981-91, 1996/01 (PubMed)

Zlatanova, van Holde:
"Binding to four-way junction DNA: a common property of architectural proteins?"
In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology , Vol. 12, Issue 6, pp. 421-31, 1998/01 (PubMed)