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Détail du produit pour High Mobility Group 1 antibody
High Mobility Group 1 antibody
Aperçu
| Antigène: | High Mobility Group 1 |
| Type anticorps: | Polyclonal |
| Application: | Western Blotting (WB) |
| Hôte: | Rabbit |
| Quantité: | |
| Prix: | 400,00 € (Plus frais de livraison et TVA) |
| Numéro de commande: | ABIN123797 |
| Disponibilité: | Ships in 1 to 2 days. |
Description du produit: High Mobility Group 1 antibody
| Antigène | High Mobility Group 1 |
| Type anticorps | Polyclonal |
| Format | Liquid. Supplied as high titer anti-serum. |
| Description | High mobility group 1 (HMG1) is a 26 k Da highly conserved non-sequence-specific DNA-binding nuclear protein. Mammalian HMG1 has two homologous DNA-binding domains HMG boxes, A and B (each of 80?90 amino-acid residues), linked by a short basic region to an acidic C-terminal domain containing 30 consecutive Asp and Glu residues. HMG1 has been implicated in a number of fundamental biological processes including transcription, replication and recombination, in which it plays a role in manipulating DNA structure by bending, looping, compaction or unwinding, or by direct contacts with distinct cellular proteins. HMG1 can act as a repressor, by interacting with TBP to block pre-initiation complex formation or as an activator, by facilitating the binding of various transcription factors to their cognate DNA sequences. Most recently, it was discovered that HMG1 is a late mediator of delayed endotoxin lethality by activating downstream cytok ine release. |
| Hôte | Rabbit |
| Specificité | Alpha-HMG1 reacts with the HMG1 protein in HeLa nuclear extract by Western blotting. |
Applications: High Mobility Group 1 antibody
| Application | Western Blotting (WB) |
| Indications d'application | Recommended dilution range for Western blot analysis: 1:2000 - 1:5000. |
| Stock | Store at -80 °C, avoid freeze/thaw cycles. Shipped on dry ice. Shelf Life: 12 months. |
| Restrictions | For Research Use only. |
Références: High Mobility Group 1 antibody
| Références |
Bianchi, Beltrame, Paonessa: "Specific recognition of cruciform DNA by nuclear protein HMG1." In: Science (New York, N.Y.) , Vol. 243, Issue 4894 Pt 1, pp. 1056-9, 1989/01 (PubMed) Bustin, Lehn, Landsman: "Structural features of the HMG chromosomal proteins and their genes." In: Biochimica et biophysica acta , Vol. 1049, Issue 3, pp. 231-43, 1990/01 (PubMed) Ge, Roeder: "The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein." In: The Journal of biological chemistry , Vol. 269, Issue 25, pp. 17136-40, 1994/01 (PubMed) Jayaraman, Moorthy, Murthy et al.: "High mobility group protein-1 (HMG-1) is a unique activator of p53." In: Genes & development , Vol. 12, Issue 4, pp. 462-72, 1998/01 (PubMed) Lu, Peterson, Dasgupta et al.: "Influence of HMG-1 and adenovirus oncoprotein E1A on early stages of transcriptional preinitiation complex assembly." In: The Journal of biological chemistry , Vol. 275, Issue 45, pp. 35006-12, 2000/01 (PubMed) Onate, Prendergast, Wagner et al.: "The DNA-bending protein HMG-1 enhances progesterone receptor binding to its target DNA sequences." In: Molecular and cellular biology , Vol. 14, Issue 5, pp. 3376-91, 1994/01 (PubMed) Stelzer, Goppelt, Lottspeich et al.: "Repression of basal transcription by HMG2 is counteracted by TFIIH-associated factors in an ATP-dependent process." In: Molecular and cellular biology , Vol. 14, Issue 7, pp. 4712-21, 1994/01 (PubMed) Yang, Wang, Tracey: "HMG-1 rediscovered as a cytokine." In: Shock (Augusta, Ga.) , Vol. 15, Issue 4, pp. 247-53, 2001/01 (PubMed) Zappavigna, Falciola, Helmer-Citterich et al.: "HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation." In: The EMBO journal , Vol. 15, Issue 18, pp. 4981-91, 1996/01 (PubMed) Zlatanova, van Holde: "Binding to four-way junction DNA: a common property of architectural proteins?" In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology , Vol. 12, Issue 6, pp. 421-31, 1998/01 (PubMed) |
Informations supplémentaires: High Mobility Group 1 antibody
| Google Scholar | Trouver des références supplémentaires pour antigène alpha-HMG1 sur Google Scholar™ |
| EMBL Harvester | Recherche humain, souris ou rat génome pour antigène alpha-HMG1 (Bioinformatic Harvester (EMBL)) |
