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Product details for Hip (Chicken) antibody
Hip (Chicken) antibody
Overview
| Antigen: | HSC70 interacting Protein (Hip) |
| Antibody Type: | Monoclonal |
| Application: | Immunoprecipitation (IP), Western Blotting (WB) |
| Reactivity: | Chicken, Human, Rabbit |
| Host: | Mouse |
| Quantity: | |
| Price: | 448,63 $ (Plus shipping costs and VAT, Invoice in EUR) |
| Order number: | ABIN121013 |
| Availability: | Ships in 3 to 10 days |
Additional Information: Hip (Chicken) antibody
| Antigen | HSC70 interacting Protein (Hip) |
| Immunogen | Recombinant human Hip protein. |
| Reactivity | Chicken, Human, Rabbit |
| Antibody Type | Monoclonal |
| Format | Purified |
| Isotype | IgG »Matching secondary antibodies |
| Clone | 2G6 |
| Host | Mouse |
| Specificity | Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP90, HSP70), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 &, FKBP54 and the cyclosporin binding protein, CyP-40) and three other proteins termed p23, p60 and heat shock cognate protein 70 kDa (HSC70)-interacting protein (Hip), also known as p48. Hip, along with HSP70 and p60, combine with steroid receptors as transient intermediate complex members. In vitro studies have suggested that Hip transiently interacts with progesterone receptor in a cell free system prior to hormone binding competency and dissociates from the receptor complex with the binding of an HSP90:Immunophilin:p23 subcomplex which then results in a hormone-binding-competent receptor complex. While neither its exact function nor mechanism of action have been identified, Hip appears to be an important factor in steroid receptor function. Hip also appears to regulate the function of HSC70 in an ATP hydrolysis and HSP40 dependent fashion. This antibody detects heat shock cognate protein 70 kDa (HSC70)-interacting protein (Hip) from human, chicken and rabbit samples. This antibody has been successfully used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects a 48 kDa protein representing Hip from rabbit reticulocyte lysate. ABIN121013 antigen is recombinant human Hip protein. |
Application Details: Hip (Chicken) antibody
| Application | Immunoprecipitation (IP), Western Blotting (WB) |
| Application Notes | Western Blot: 1ug/ml. Immunoprecipitation. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user. |
| Buffer | This antibody is supplied as liquid, in 50 ul PBS containing 0.05% sodium azide as preservative. |
| Storage | Store the antibody at –20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Research Area | Serum/Plasma Proteins, Heat Shock Proteins |
| Restrictions | Research only |
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