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Product details for Hypoxia Inducible Factor-1 alpha (H1alpha67) (Human) anti...
Hypoxia Inducible Factor-1 alpha (H1alpha67) (Human) antibody
Overview
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| Antigen: | Hypoxia Inducible Factor-1 alpha (H1alpha67) |
| Antibody Type: | Monoclonal |
| Reactivity: | Human, Mouse (Murine), Rat, Rabbit |
| Host: | Mouse |
| Quantity: | |
| Price: | 361,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN137035 |
| Availability: | 7 to 10 days until shipment |
Additional Information: Hypoxia Inducible Factor-1 alpha (H1alpha67) (Human) antibody
| Antigen | Hypoxia Inducible Factor-1 alpha (H1alpha67) |
| Immunogen | Amino acids 432-528 of human HIF-1alpha. |
| Reactivity | Human, Mouse (Murine), Rat, Rabbit |
| Antibody Type | Monoclonal |
| Format | Liquid |
| Isotype | IgG2b »Matching secondary antibodies |
| Description | Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein that activates gene transcription in response to reduced cellular 02 concentration. HIF-1 activates the transcription of EPO, VEGF, iNOS, heme oxygenase 1 and several other critical intracellular responses to hypoxia. HIF-1 is a heterodimer composed of HIF-1a and HIF-1b subunits. Both subunits are induced by hypoxia and rapidly decay upon return to normoxia and are basic-helix-loop-helix-PAS proteins. Recent research indicates the ability to regulate hypoxia-inducible factors may be related to tumor-related angiogenesis in certain cancers. |
| Clone | H1alpha67 |
| Host | Mouse |
| Specificity | This antibody is specific for HIF-1 alpha. |
Application Details: Hypoxia Inducible Factor-1 alpha (H1alpha67) (Human) antibody
| Application Notes | For WB: Use at a dilution of 1:500. By Western blot, this antibody recognizes bands at 120 kDa representing HIF-1 alpha in induced tissues and cells. Multiple bands may be seen at 120 kDa representing post-translational modification of HIF-1alpha. This antibody has also been used to immunoprecipitate human HIF-1 alpha. For IHC-P: Use at a dilution of 1:25. For IP: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/cancentrations should be determined by researcher. |
| Concentration | 1.5 mg/ml |
| Purity | Protein G purified |
| Buffer | Phosphate-buffered saline containing 0.05% sodium azide. |
| Restrictions | For research use only |
Publications: Hypoxia Inducible Factor-1 alpha (H1alpha67) (Human) antibody
| Publications |
Catrina, Botusan, Rantanen et al.: "Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I." In: Clinical cancer research : an official journal of the American Association for Cancer Research , Vol. 12, Issue 15, pp. 4506-14, 2006/01 (PubMed) |
External Information: Hypoxia Inducible Factor-1 alpha (H1alpha67) (Human) antibody
| Google Scholar | Find more references for clone H1alpha67 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen Hypoxia Inducible Factor-1 alpha (H1alpha67) (Bioinformatic Harvester (EMBL)) |
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