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Product details for ICAD (Human) antibody
ICAD (Human) antibody
Overview
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| Antigen: | ICAD |
| Antibody Type: | Polyclonal |
| Application: | Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
| Reactivity: | Human |
| Host: | Rabbit |
| Quantity: | |
| Price: | 271,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN146708 |
| Availability: | 7 to 10 days until shipment |
Additional Information: ICAD (Human) antibody
| Antigen | ICAD |
| Immunogen | Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (N terminal). |
| Reactivity | Human |
| Antibody Type | Polyclonal |
| Format | Liquid |
| Isotype | IgG »Matching secondary antibodies |
| Description | Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the Caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human DNA fragmentation factor (DFF) was identified recently which was cleaved by Caspase 3 during apoptosis. A mouse homologue of human DFF was identified as inhibitor of caspase activated deoxyribonuclease (ICAD). Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which causes DNase activation and DNA degradation, is the hallmark of apoptotic cell death. |
| Host | Rabbit |
Application Details: ICAD (Human) antibody
| Application | Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
| Application Notes | IHC-P: Ready diluted. For 10 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Purity | Immunogen affinity purified |
| Buffer | Preservative: Sodium AzideConstituents: BSA, 10mM PBS. pH 7.4 |
| Storage | Store at 4 C. |
| Restrictions | For research use only |
External Information: ICAD (Human) antibody
| Google Scholar | Find more references for antigen ICAD on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen ICAD (Bioinformatic Harvester (EMBL)) |
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