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Product details for ICAD (Human) antibody
ICAD (Human) antibody
Overview
| Antigen: | ICAD |
| Antibody Type: | Polyclonal |
| Application: | Immunohistochemistry (IHC), Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Rabbit |
| Quantity: | |
| Price: | 242,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN146905 |
| Availability: | 7 to 10 days until shipment |
Additional Information: ICAD (Human) antibody
| Antigen | ICAD |
| Immunogen | Peptide corresponding to amino acids 2 to 21 ofhuman DFF45 (1). |
| Reactivity | Human |
| Antibody Type | Polyclonal |
| Format | Liquid |
| Isotype | IgG »Matching secondary antibodies |
| Description | Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human 45 kDa DNA fragmentation factor (DFF45) was identified recently which was cleaved by caspase-3 during apoptosis (1). Mouse homologue of human DFF45 was identified as a DNase inhibitor designated ICAD (2,3). DFF45/ICAD have short forms that were termed DFF35and ICADs, respectively, (2,4). Upon cleavage ofDFF45/ICAD, the caspase activated deoxyribonuclease (DFF40/CAD) is released and activated and eventually causes the degradation of DNA in the nuclei (2-5). Therefore, the cleavage of DFF45/ICAD, which causesDFF40/CAD activation and DNA degradation, is the hallmark of apoptotic cell death. |
| Host | Rabbit |
Application Details: ICAD (Human) antibody
| Application | Immunohistochemistry (IHC), Western Blotting (WB) |
| Application Notes | Western blot at 1:1000 to 1:2000 dilution. |
| Concentration | 0.5 mg/ml |
| Purity | IgG fraction |
| Buffer | PBS with 0.02% sodium azide |
| Storage | Store at4 C, stable for one year. |
| Restrictions | For research use only |
External Information: ICAD (Human) antibody
| Google Scholar | Find more references for antigen ICAD on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen ICAD (Bioinformatic Harvester (EMBL)) |
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