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Product details for ICAD (Mouse) antibody
ICAD (Mouse) antibody
Overview
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| Antigen: | ICAD |
| Antibody Type: | Polyclonal |
| Application: | Western Blotting (WB) |
| Reactivity: | Mouse (Murine) |
| Host: | Rabbit |
| Quantity: | |
| Price: | 349,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN149536 |
| Availability: | 7 to 10 days until shipment |
Additional Information: ICAD (Mouse) antibody
| Antigen | ICAD |
| Immunogen | Synthetic peptide, corresponding to amino acids 2-21 of Mouse ICAD . |
| Reactivity | Mouse (Murine) |
| Antibody Type | Polyclonal |
| Isotype | IgG »Matching secondary antibodies |
| Description | Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human DNA fragmentation factor (DFF) was identified recently which is cleaved by caspase-3 during apoptosis (1). Mouse homologue of human DFF was identified as a DNase inhibitor designated ICAD, for inhibitor of caspase-activated DNase (2,3). Upon cleavage of DFF/ICAD, a caspase-activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei (2,3). Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which causes DNase activation and DNA degradation, is the hallmark of apoptotic cell death (4). |
| Host | Rabbit |
Application Details: ICAD (Mouse) antibody
| Application | Western Blotting (WB) |
| Application Notes | WB: Use at a dilution of 1/500-1/1000. Predicted molecular weight: 45 kDa. Can be blocked with GTX28459 ICAD (N-term) peptide (mouse) Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | 0.5 mg/ml |
| Purity | IgG fraction |
| Buffer | Preservative: 0.02% Sodium AzideConstituents: PBS |
| Storage | Storeat 4 C, stable for one year. |
| Restrictions | For research use only |
External Information: ICAD (Mouse) antibody
| Google Scholar | Find more references for antigen ICAD on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen ICAD (Bioinformatic Harvester (EMBL)) |
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