IKK gamma (Human) antibody

Overview

Antigen	I Kappa K gamma (IkKg) (C-term)
Immunogen	C-terminus of the IKK-gamma protein (proprietary)
Reactivity	Human
Antibody Type	Polyclonal
Format	Aff - Purified
Description	Pro-inflammatory cytokines activate the transcription factor NF-kappa B by stimulatingthe activity of a protein kinase that phosphorylates Ikappa B, an inhibitor of NF-kappa B,at sites that trigger its ubiquitination and degradation. A large, cytokine-responsiveIkappa B kinase (IKK) complex has been purified and the genes encoding 2 of itssubunits have been cloned. These subunits, IKK-alpha and Ikk-beta, are proteinkinases whose function is needed for NF-kappa B activation by pro-inflammatory stimuli. IKK is composed of similar amounts of IKK-alpha, Ikk-beta, which are differentiallyprocessed forms of a third subunit, IKK-gamma. Ikk-gamma interacts preferentially withIKK-beta and is required for the activation of the IKK complex.
Host	Rabbit
Specificity	Reacts with residues 385-399 [RRSPPEEPPDFCCPK] of the IKK-g protein. Recognizes both human isoforms. Human. Other species have not been tested.

Application	Western Blotting (WB)
Application Notes	Western blot Use at 1:500 to 1:1,000 dilution. However, the investigator shoulddetermine the optimal dilution for a specificapplication such as immunohistochemistry.
Concentration	1 mg/ml
Buffer	100 ug in 100 ul (1 mg/ml) in PBS containing 0.02% sodium azide. PBS with 0.02% sodium azide
Storage	Store at +2-8°C for 3 months or -20°C for longer periods. Avoid repeated freeze-thawcycles.
Restrictions	For Research Use only

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