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Produktdetails für Insulin Receptor beta (Human) antibody
Insulin Receptor beta (Human) antibody
Übersicht
| Antigen: | Insulin Receptor beta |
| Antikörper-Typ: | Monoklonal |
| Applikation: | Enzyme Immunoassay (EIA), Immunoprecipitation (IP) |
| Reaktivität: | Human, Mouse (Murine), Rat |
| Wirt: | Mouse |
| Menge: | |
| Preis: | 271,00 € (Zzgl. Versandkosten und MWSt) |
| Bestellnummer: | ABIN145243 |
| Verfügbarkeit: | 7 to 10 days until shipment |
Produktbeschreibung: Insulin Receptor beta (Human) antibody
| Antigen | Insulin Receptor beta |
| Immunogen | Synthetic peptide: GKKNGRILTLPRSNPS, corresponding to amino acids 1367-1382 of Human Insulin Receptor. |
| Reaktivität | Human, Mouse (Murine), Rat |
| Antikörper-Typ | Monoklonal |
| Format | Liquid |
| Isotyp | IgG1 »Passende Sekundärantikörper |
| Beschreibung | IR is a receptor tyrosine kinase which mediates the biological activities of insulin by regulating multiple signaling pathways through activation of a series of phosphorylation cascades. The receptor is a disulfide linked heterotetrameric glycoprotein consisting of two alpha subunits and two beta subunits arranged in the following configuration: beta-alpha-alpha-beta. The alpha subunits each contain insulin binding sites and are entirely extracellular in localization. The beta subunits each possess an extracellular domain, a single transmembrane domain, and a cytoplasmic tyrosine kinase domain. Binding of insulin to the alpha subunits induces a conformation change in the receptor which activates the kinase domain, stimulating tyrosine autophosphorylation of the receptor and tyrosine phosphorylation of at least five different insulin receptor substrates designated IRS-1-4, and Shc. |
| Klon | CT-1 |
| Wirt | Mouse |
| Spezifität | This antibody is specific for the approximately 95 kDa IR and shows no cross-reactivity with insulin like growth factor (IGF) receptors. Phosphorylation of the threonine residue within this sequence (corresponding to threonine 1348) decreases the affinity |
Anwendungen: Insulin Receptor beta (Human) antibody
| Applikation | Enzyme Immunoassay (EIA), Immunoprecipitation (IP) |
| Applikationshinweise | EIA: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Konzentration | 0.2 mg/ml |
| Reinheit | Protein G purified |
| Buffer | Preservative: 0.09% Sodium AzideConstituents: 0.2% BSA, PBS. pH 7.4 |
| Beschränkungen | For research use only |
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