MDA5 (Human) antibody

Overview

Antigen	MDA5
Immunogen	Synthetic peptide: SNGYSTDENFRYL from N Terminus of the protein sequence according to NP_071451.
Reactivity	Human
Antibody Type	Polyclonal
Format	Liquid
Isotype	IgG »Matching secondary antibodies
Description	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon( IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents, treatment with either agent alone only achieves reversible differentiation.
Host	Goat

Application Notes	Tested in peptide ELISA antibody detection limit dilution >1/32000. Western Blot: No signal obtained yet but low background observed in Human Placenta lysate at up to 1ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Concentration	0.5 mg/ml
Purity	Immunogen affinity purified
Buffer	Preservative: 0.02% Sodium AzideConstituents: 0.5% BSA, Tris-saline. pH 7.3
Restrictions	For research use only

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