MDA5 (Human) antibody

概述


	抗原:	MDA5
	抗体类型:	多克隆抗体
	应用范围:	Western Blotting (WB)
	目标物种:	Human
	抗体来源:	Rabbit
	规格:	100ug
	价格:	315,00 € (加上运费和增值税)
	货号:	ABIN195468
	发货时间:	10 days until shipment

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详细信息: MDA5 (Human) antibody

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抗原	MDA5
免疫原	Synthetic peptide of part of N terminal of human MDA5 (TIEDRNRIAAAENNGN)
目标物种	Human
抗体类型	多克隆抗体
状态	Affinity purified
抗体同种型	IgG »相配的二抗
描述	A full-length cDNA encoding MDA5 was isolated by screening a melanoma differentiation-subtracted library and a placenta cDNA library, also known as Ifih1(Interferon induced with helicase C domain protein 1). Yoneyama et al. have identified a DExD/H box-containing RNA helicase, retinoic acid inducible gene I (RIG-I), as an essential component of the sensor of intracellular dsRNA (1). Furthermore, two other DexD/H-box-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database (2). MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIG-I/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses.
抗体来源	Rabbit

使用细节: MDA5 (Human) antibody

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应用范围	Western Blotting (WB)
应用备注	Western blotting in concentration of 1 – 5?g/mL
纯化	Purified with antigen peptide
缓冲液	Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
贮藏	Lyophilized product, 5 years at 2 – 8 ?. Solution, 2 years at –20 ?. 1.0 mL deionized water will be added to the product (the conc. comes up 100ug/ml)
研究领域	Virology, Immunology
限制	For Research Use only

图像: MDA5 (Human) antibody

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lane 1: HeLa cell lysate without IFN beta stimulation. lane 2: HeLa cell lysate with IFN beta stimulation. When this antibody is used in Western Blotting, several bands appear although the antibody specifically detects the MDA5 protein. We recommend to perform positive and negative controls in parallel.

图像 MDA5 (Human) antibody (1)