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Produktdetails für  MDA5 (Human) antibody

MDA5 (Human) antibody

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Bild für MDA5 (Human) antibody
Antigen: MDA5
Antikörper-Typ: Polyklonal
Applikation: Western Blotting (WB)
Reaktivität: Human
Wirt: Rabbit
Menge: 100ug
Preis: 315,00 €   (Zzgl. Versandkosten und MWSt)
Bestellnummer: ABIN195468
Verfügbarkeit: 10 days until shipment
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Produktbeschreibung:  MDA5 (Human) antibody

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Antigen MDA5
Immunogen Synthetic peptide of part of N terminal of human MDA5 (TIEDRNRIAAAENNGN)
Reaktivität Human
Antikörper-Typ Polyklonal
Format Affinity purified
Isotyp IgG »Passende Sekundärantikörper
Beschreibung A full-length cDNA encoding MDA5 was isolated by screening a melanoma differentiation-subtracted library and a placenta cDNA library, also known as Ifih1(Interferon induced with helicase C domain protein 1). Yoneyama et al. have identified a DExD/H box-containing RNA helicase, retinoic acid inducible gene I (RIG-I), as an essential component of the sensor of intracellular dsRNA (1). Furthermore, two other DexD/H-box-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database (2). MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIG-I/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses.
Wirt Rabbit

Anwendungen:  MDA5 (Human) antibody

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Applikation Western Blotting (WB)
Applikationshinweise Western blotting in concentration of 1 – 5?g/mL
Reinigung Purified with antigen peptide
Buffer Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Lagerung Lyophilized product, 5 years at 2 – 8 ?. Solution, 2 years at –20 ?. 1.0 mL deionized water will be added to the product (the conc. comes up 100ug/ml)
Forschungsgebiet Virology, Immunology
Beschränkungen For Research Use only

Bilder:  MDA5 (Human) antibody

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lane 1: HeLa cell lysate without IFN beta stimulation. lane 2: HeLa cell lysate with IFN beta stimulation. When this antibody is used in Western Blotting, several bands appear although the antibody specifically detects the MDA5 protein. We recommend to perform positive and negative controls in parallel.

Bild für MDA5 (Human) antibody (1)

Weitere Informationen:  MDA5 (Human) antibody

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EMBL Harvester Genom von Mensch, Maus oder Ratte nach Antigen MDA5 durchsuchen (Bioinformatic Harvester (EMBL))