BASKET
HELP
Product details for PARP (Human) antibody
PARP (Human) antibody
Overview
| Antigen: | PARP |
| Antibody Type: | Monoclonal |
| Reactivity: | Human, Mouse (Murine), Rat, Hamster |
| Host: | Mouse |
| Quantity: | |
| Price: | 414,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN137692 |
| Availability: | 7 to 10 days until shipment |
Additional Information: PARP (Human) antibody
| Antigen | PARP |
| Immunogen | Purified calf thymus poly(ADP-ribose) polymerase (PARP) |
| Reactivity | Human, Mouse (Murine), Rat, Hamster |
| Antibody Type | Monoclonal |
| Format | Liquid |
| Isotype | IgG1 »Matching secondary antibodies |
| Description | Poly(ADP-ribose) polymerase (PARP), a nuclear enzyme often termed a molecular nick sensor, recognizes and binds to DNA single or double strand breaks through the N-terminal DNA binding domain sensor. The activation of PARP is one of the first responses to DNA strand interruptions. The DNA-bound, catalytically activated PARP synthesizes poly(ADP-ribose)(pADPr) on nuclear target proteins such as topoisomerase, histones, and PARP itself. Although the exact role of PARP is not well known, it has been implicated in different cellular responses to genotoxic damage. These responses include cell survival and death, transformation, and DNA repair. Additional studies have demonstrated the role of PARP in the death of neuronal cells after ischemia-reperfusion injury, as well as maintaining the genomic integrity and survival responses of PARP knockout mice after exposure to whole body gamma-irradiation. |
| Clone | C-2-10 |
| Host | Mouse |
| Specificity | Recognizes 116 kDa PARP and the 85 kDa apoptosis-related cleavage fragment. Epitope is in the C-terminal part of the DNA binding domain of PARP. |
Application Details: PARP (Human) antibody
| Application Notes | Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. |
| Concentration | 0.2 mg/ml |
| Purity | Protein A purified |
| Buffer | Phosphate-buffered saline containing 0.2% BSA and 0.02% sodium azide. |
| Storage | For long-term storage, aliquot into individual working vials and store at -70 degrees C. Avoid repeated freeze-thaw cycles. |
| Restrictions | For research use only |
External Information: PARP (Human) antibody
| Google Scholar | Find more references for clone C-2-10 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen PARP (Bioinformatic Harvester (EMBL)) |
browse antibodies by
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
