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Product details for TLR6 (Human) antibody
TLR6 (Human) antibody
Overview
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| Antigen: | Toll-like Receptor 6 (TLR6) |
| Antibody Type: | Monoclonal |
| Application: | Flow Cytometry (FACS) |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 84,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN197801 |
| Availability: | Ships within 1 day |
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Additional Information: TLR6 (Human) antibody
| Antigen | Toll-like Receptor 6 (TLR6) |
| Immunogen | Synthetic peptide corresponding to amino acids 408-424 of human TRL6 |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Format | Purified |
| Isotype | IgG1 »Matching secondary antibodies |
| Clone | 86B1153 |
| Host | Mouse |
| Specificity | The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. The amino acid sequence of human TLR6 is most similar to hTLR1 with 69% identity at the amino acid level. Human TLR6 consists of a predicted 807 amino acids with a molecular weight of approximately 92 kDa (3). Human and mouse TLR6 share an amino acid identity of 73%. TLR6 activates both NF-kB and c-Jun N-terminal Kinase (JNK). The amino acids in the cytoplasmic domain of IL-1 receptor, which are critical for NF-kB activation, are conserved in TLR6. It has also been shown that TLR2-mediated response to a phenol-soluble factor from staphylococcus epidermidis is enhanced by TLR6 (4). TLR6 is predominantly expressed in spleen, thymus, ovary, and lung (3). This antibody is specific for human TLR6 and will not cross-react with mouse TLR6 or other TLR |
Application Details: TLR6 (Human) antibody
| Application | Flow Cytometry (FACS) |
| Application Notes | Flow cytometry analysis at 3-5 |
| Format | Purified |
| Concentration | 0.5 mg/ml |
| Buffer | This antibody is supplied as liquid IgG purified on Protein G in PBS, pH 7.2, with 0.1% sodium azide. Intracellular FACS analysis of TLR6 (shaded peak) and mouse IgG1 isotype control (open peak) in 106 Ramos cells using 3 |
| Storage | Store the antibody at 4-8 |
| Research Area | Signaling, Immunology, Inflammation |
| Restrictions | Research only |
Images: TLR6 (Human) antibody
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Intracellular FACS analysis of TLR6 (shaded peak) and mouse IgG1 isotype control (open peak) in 106 Ramos cells using 3 ug of ABIN121322 |
External Information: TLR6 (Human) antibody
| Google Scholar | Find more references for clone 86B1153 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen Toll-like Receptor 6 (TLR6) (Bioinformatic Harvester (EMBL)) |
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