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产品详细信息： TSC1/Hamartin (T1149) (Human) antibody
TSC1/Hamartin (T1149) (Human) antibody
概述
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| 抗原: | TSC1/Hamartin (T1149) |
| 抗体类型: | 多克隆抗体 |
| 应用范围: | Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
| 目标物种: | Human |
| 抗体来源: | Rabbit |
| 规格: | |
| 价格: | 315,00 € (加上运费和增值税) |
| 货号: | ABIN195469 |
| 发货时间: | 10 days until shipment |
详细信息: TSC1/Hamartin (T1149) (Human) antibody
| 抗原 | TSC1/Hamartin (T1149) |
| 免疫原 | The synthetic peptide of a part of Human TSC1/Hamartin (GQLHIMDYNETHHEHS) |
| 目标物种 | Human |
| 抗体类型 | 多克隆抗体 |
| 状态 | Affinity purified |
| 抗体同种型 | IgG »相配的二抗 |
| 描述 | TSC1 is a tumor-suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa (ref. 1). Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, TSC1 knockout mouse develops a renal tumor (ref. 2). TSC1/Hamartin, a product of TSC1, forms a complex with TSC2/Tuberin (ref. 3), a product of another tumor-suppressor gene TSC2 in cytoplasm (ref. 4). The complex suppresses mTOR activity and regulates cellular growth and division in a insulin signaling pathway (ref. 5). Under the condition of proliferation stimulus, forming of the complex is inhibited, and as a result, suppression to mTOR comes off and it leads to cellular growth and division. |
| 抗体来源 | Rabbit |
| 特异性 | Crossreactivities with mouse |
使用细节: TSC1/Hamartin (T1149) (Human) antibody
| 应用范围 | Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
| 应用备注 | This antibody can be stained in formalin fixed paraffin embedded tissues by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 1 - 5 ?g /mL, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 1 - 5 ?g /mL. |
| 纯化 | Purified with antigen peptide |
| 缓冲液 | Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 |
| 贮藏 | Lyophilized product, 5 years at 2 – 8 ?. Solution, 2 years at –20 ?. 1.0 mL deionized water will be added to the product (the conc. comes up 100ug/ml) |
| 研究领域 | Cancer, Diabetes |
| 限制 | For Research Use only |
外部连接: TSC1/Hamartin (T1149) (Human) antibody
| Google Scholar | 抗原 TSC1/Hamartin (T1149) |
| EMBL Harvester | 在human, mouse 或 rat 基因组里搜索抗原TSC1/Hamartin (T1149) (Bioinformatic Harvester (EMBL)) |
