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Produktdetails für TSC1/Hamartin (T1149) (Human) antibody
TSC1/Hamartin (T1149) (Human) antibody
Übersicht
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| Antigen: | TSC1/Hamartin (T1149) |
| Antikörper-Typ: | Polyklonal |
| Applikation: | Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
| Reaktivität: | Human |
| Wirt: | Rabbit |
| Menge: | |
| Preis: | 315,00 € (Zzgl. Versandkosten und MWSt) |
| Bestellnummer: | ABIN195469 |
| Verfügbarkeit: | 10 days until shipment |
Produktbeschreibung: TSC1/Hamartin (T1149) (Human) antibody
| Antigen | TSC1/Hamartin (T1149) |
| Immunogen | The synthetic peptide of a part of Human TSC1/Hamartin (GQLHIMDYNETHHEHS) |
| Reaktivität | Human |
| Antikörper-Typ | Polyklonal |
| Format | Affinity purified |
| Isotyp | IgG »Passende Sekundärantikörper |
| Beschreibung | TSC1 is a tumor-suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa (ref. 1). Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, TSC1 knockout mouse develops a renal tumor (ref. 2). TSC1/Hamartin, a product of TSC1, forms a complex with TSC2/Tuberin (ref. 3), a product of another tumor-suppressor gene TSC2 in cytoplasm (ref. 4). The complex suppresses mTOR activity and regulates cellular growth and division in a insulin signaling pathway (ref. 5). Under the condition of proliferation stimulus, forming of the complex is inhibited, and as a result, suppression to mTOR comes off and it leads to cellular growth and division. |
| Wirt | Rabbit |
| Spezifität | Crossreactivities with mouse |
Anwendungen: TSC1/Hamartin (T1149) (Human) antibody
| Applikation | Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
| Applikationshinweise | This antibody can be stained in formalin fixed paraffin embedded tissues by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 1 - 5 ?g /mL, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 1 - 5 ?g /mL. |
| Reinigung | Purified with antigen peptide |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 |
| Lagerung | Lyophilized product, 5 years at 2 – 8 ?. Solution, 2 years at –20 ?. 1.0 mL deionized water will be added to the product (the conc. comes up 100ug/ml) |
| Forschungsgebiet | Cancer, Diabetes |
| Beschränkungen | For Research Use only |
Weitere Informationen: TSC1/Hamartin (T1149) (Human) antibody
| Google Scholar | Suchen Sie in Google Scholar™ nach weiteren Artikeln für Antigen TSC1/Hamartin (T1149) |
| EMBL Harvester | Genom von Mensch, Maus oder Ratte nach Antigen TSC1/Hamartin (T1149) durchsuchen (Bioinformatic Harvester (EMBL)) |
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